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Azaserine

Azaserine
Clinical data
ATC code
  • none
Identifiers
  • O-(2-Diazoacetyl)-L-serine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.003.692 Edit this at Wikidata
Chemical and physical data
FormulaC5H7N3O4
Molar mass173.128 g·mol−1
3D model (JSmol)
  • O=C(OC[C@H](N)C(O)=O)/C=[N+]=[N-]
  • InChI=1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1 checkY
  • Key:MZZGOOYMKKIOOX-VKHMYHEASA-N checkY
 ☒NcheckY (what is this?)  (verify)

Azaserine is a naturally occurring serine derivative diazo compound with antineoplastic and antibiotic properties deriving from its action as a purinergic antagonist and structural similarity to glutamine. Azaserine acts by competitively inhibiting glutamine amidotransferase, a key enzyme responsible for glutamine metabolism.


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