Bcl-2

BCL2
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG
معین‌کننده‌ها
نام‌های دیگر	BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-2
شناسه‌های بیرونی	OMIM: 151430 MGI: 88138 HomoloGene: 527 GeneCards: BCL2
موقعیت ژن (موش) کروموزوم کروموزوم ۱ (موش)[۱] نوار 1 E2.1|1 49.76 cM شروع 106,465,908 bp[۱] پایان 106,642,004 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • protein phosphatase binding • transcription factor binding • protein phosphatase 2A binding • channel inhibitor activity • protein homodimerization activity • channel activity • protease binding • GO:0001948، GO:0016582 پیوند پروتئینی • sequence-specific DNA binding • BH3 domain binding • identical protein binding • protein heterodimerization activity • ubiquitin protein ligase binding ترکیبات سلولی • سیتوپلاسم • سیتوزول • پوشش هسته‌ای • membrane • میتوکندری • هسته یاخته • mitochondrial membranes • myelin sheath • mitochondrial outer membrane • شبکه آندوپلاسمی • pore complex • integral component of membrane • intracellular anatomical structure • endoplasmic reticulum membrane • نوکلئوپلاسم • GO:0009327 protein-containing complex فرایند زیستی • GO:1904089 negative regulation of neuron apoptotic process • intrinsic apoptotic signaling pathway in response to oxidative stress • ureteric bud development • renal system process • organ growth • T cell differentiation in thymus • lymphocyte homeostasis • response to steroid hormone • GO:0048554 positive regulation of catalytic activity • ear development • glomerulus development • post-embryonic development • cellular response to DNA damage stimulus • T cell homeostasis • negative regulation of ossification • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • positive regulation of smooth muscle cell migration • regulation of protein localization • T cell differentiation • B cell lineage commitment • پاسخ به ایسکمی • regulation of mitochondrial membrane permeability • humoral immune response • defense response to virus • mesenchymal cell development • positive regulation of multicellular organism growth • animal organ morphogenesis • developmental pigmentation • hair follicle morphogenesis • B cell differentiation • تکثیر سلولی • metanephros development • melanocyte differentiation • negative regulation of autophagy • positive regulation of neuron maturation • negative regulation of myeloid cell apoptotic process • cellular response to hypoxia • pigment granule organization • negative regulation of cell population proliferation • B cell receptor signaling pathway • cellular response to organic substance • regulation of apoptotic process • response to cytokine • cellular response to glucose starvation • regulation of protein stability • استخوان‌سازی • positive regulation of melanocyte differentiation • axon regeneration • kidney development • actin filament organization • thymus development • negative regulation of intrinsic apoptotic signaling pathway • negative regulation of apoptotic signaling pathway • response to nicotine • spleen development • endoplasmic reticulum calcium ion homeostasis • positive regulation of skeletal muscle fiber development • GO:0001306 پاسخ به استرس اکسیداتیو • lymphoid progenitor cell differentiation • positive regulation of peptidyl-serine phosphorylation • CD8-positive, alpha-beta T cell lineage commitment • reactive oxygen species metabolic process • negative regulation of retinal cell programmed cell death • branching involved in ureteric bud morphogenesis • gland morphogenesis • positive regulation of cell growth • positive regulation of B cell proliferation • negative regulation of cell growth • واکنش به پرتو گاما • positive regulation of intrinsic apoptotic signaling pathway • response to toxic substance • digestive tract morphogenesis • neuron apoptotic process • male gonad development • regulation of protein heterodimerization activity • regulation of glycoprotein biosynthetic process • regulation of viral genome replication • female pregnancy • negative regulation of mitochondrial depolarization • GO:0016576 protein dephosphorylation • protein polyubiquitination • cellular calcium ion homeostasis • B cell homeostasis • behavioral fear response • oocyte development • regulation of cell-matrix adhesion • response to iron ion • negative regulation of cell migration • regulation of autophagy • positive regulation of developmental pigmentation • developmental growth • regulation of transmembrane transporter activity • ovarian follicle development • ساماندهی بیان ژن • negative regulation of calcium ion transport into cytosol • negative regulation of osteoblast proliferation • homeostasis of number of cells within a tissue • pigmentation • response to radiation • GO:0048552 regulation of catalytic activity • peptidyl-threonine phosphorylation • regulation of protein homodimerization activity • negative regulation of anoikis • response to hydrogen peroxide • T cell lineage commitment • cochlear nucleus development • leukocyte homeostasis • regulation of programmed cell death • regulation of calcium ion transport • axonogenesis • negative regulation of cellular pH reduction • response to glucocorticoid • regulation of cell cycle • regulation of mitochondrial membrane potential • melanin metabolic process • focal adhesion assembly • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • B cell proliferation • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • immune system development • apoptotic mitochondrial changes • GO:0035404 peptidyl-serine phosphorylation • regulation of nitrogen utilization • GO:0000767 cell morphogenesis • positive regulation of cell population proliferation • negative regulation of reactive oxygen species metabolic process • response to UV-B • regulation of developmental pigmentation • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • extrinsic apoptotic signaling pathway via death domain receptors • release of cytochrome c from mitochondria • negative regulation of mitotic cell cycle • extrinsic apoptotic signaling pathway in absence of ligand • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته • transmembrane transport • intrinsic apoptotic signaling pathway in response to DNA damage • growth • cell-cell adhesion • cytokine-mediated signaling pathway • negative regulation of apoptotic process • هماتوپوئز • regulation of growth • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	596	12043
آنسامبل	ENSG00000171791	ENSMUSG00000057329
یونی‌پروت	P10415	P10417
RefSeq (mRNA)	NM_000657، XM_011526135، XM_017025917، XM_047437733، XM_047437734 NM_000633، NM_000657، XM_011526135، XM_017025917، XM_047437733، XM_047437734	NM_177410 NM_009741، NM_177410
RefSeq (پروتئین)	NP_000648، XP_011524437، XP_016881406 NP_000624، NP_000648، XP_011524437، XP_016881406	NP_803129 NP_033871، NP_803129
موقعیت (UCSC)	ن/م	Chr : 106.47 – 106.64 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

لنفومای ۲ لنفوسیت‌های بی (انگلیسی: B-cell lymphoma 2) که بیشتر با نام اختصاری Bcl-2 شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «BCL2» کُدگذاری می‌شود. این مولکول یکی از اعضای اصلی خانواده Bcl-2 است که در ساماندهی بیان ژن و همچنین القا یا مهار آپوپتوز نقش دارند.^[۴][۵] این مولکول نخستین تنظیم‌کنندهٔ آپوپتوزی بود که در موجودات زنده کشف شد.^[۶] پروتئین Bcl-2 یکی از نخستین پروتئین‌هایی که در جریان کشف فرایند جابه‌جایی کروموزومی میان کروموزوم‌های ۱۴ و ۱۸ در لنفوم فولیکولار شناسایی شد. اُرتولوگ‌های^[۷] این پروتئین در بسیاری از پستانداران کشف شده و نقشهٔ کامل ژنی آن در دسترس است. همچون BCL3، BCL5، BCL9، BCL7A، BCL6 و BCL10، این پروتئین نیز نقش مهمی در سرطان لنفوم دارد.

1. ↑ ^{۱٫۰ ۱٫۱ ۱٫۲} GRCm38: Ensembl release 89: ENSMUSG00000057329 - Ensembl, May 2017
2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ↑ Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM (Nov 1984). "Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation". Science. 226 (4678): 1097–9. Bibcode:1984Sci...226.1097T. doi:10.1126/science.6093263. PMID 6093263.
5. ↑ Cleary ML, Smith SD, Sklar J (Oct 1986). "Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation". Cell. 47 (1): 19–28. doi:10.1016/0092-8674(86)90362-4. PMID 2875799. S2CID 31493780.
6. ↑ Kelly GL, Strasser A (2020). "Toward Targeting Antiapoptotic MCL-1 for Cancer Therapy". Annual Review of Cancer Biology. 4: 299–313. doi:10.1146/annurev-cancerbio-030419-033510.
7. ↑ "OrthoMaM phylogenetic marker: Bcl-2 coding sequence". Archived from the original on 24 September 2015. Retrieved 20 December 2009.