CD18

ITGB2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1L3Y, 1YUK, 2JF1, 2P26, 2P28, 3K6S, 3K71, 3K72, 2V7D, 4NEH, 4NEN, 5E6X, 5E6V, 5E6S, 5E6R, 5E6W, 5ES4, 5E6U
Identifikatori
Aliasi	ITGB2
Vanjski ID-jevi	OMIM: 600065 MGI: 96611 HomoloGene: 20092 GeneCards: ITGB2
Lokacija gena (čovjek) Hrom. Hromosom 21 (čovjek)[1] Bend 21q22.3 Početak 44,885,953 bp[1] Kraj 44,931,989 bp[1]
Lokacija gena (miš) Hrom. Hromosom 10 (miš)[2] Bend 10 C1|10 39.72 cM Početak 77,366,086 bp[2] Kraj 77,401,542 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0032403 protein-containing complex binding • vezivanje iona metala • GO:0001948, GO:0016582 vezivanje za proteine • protein heterodimerization activity • ICAM-3 receptor activity • protein kinase binding • cell adhesion molecule binding • heat shock protein binding • amyloid-beta binding • complement component C3b binding • integrin binding • signaling receptor activity • cargo receptor activity Ćelijska komponenta • integral component of membrane • extracellular vesicle • integrin alphaL-beta2 complex • membrana • ćelijska membrana • receptor complex • cell surface • integrin complex • Egzosom • specific granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane • focal adhesion • external side of plasma membrane • integrin alphaM-beta2 complex • plasma membrane raft • Lipidni splav • cytoplasmic region • GO:0009327 makromolekulani kompleks Biološki proces • leukocyte cell-cell adhesion • endodermal cell differentiation • toll-like receptor 4 signaling pathway • positive regulation of nitric oxide biosynthetic process • heterotypic cell-cell adhesion • cell-cell signaling • GO:0010260 starenje • receptor internalization • leukocyte migration involved in inflammatory response • natural killer cell activation • cellular response to low-density lipoprotein particle stimulus • extracellular matrix organization • receptor clustering • positive regulation of angiogenesis • neutrophil chemotaxis • Ćelijska adhezija • positive regulation of NF-kappaB transcription factor activity • regulation of cell shape • regulation of immune response • cellular extravasation • integrin-mediated signaling pathway • cell-matrix adhesion • inflammatory response • endothelial cell migration • leukocyte migration • regulation of peptidyl-tyrosine phosphorylation • GO:0097285 apoptoza • Fagocitoza • neutrophil degranulation • microglial cell activation • receptor-mediated endocytosis • phagocytosis, engulfment • Ćelijska migracija • cytokine-mediated signaling pathway • positive regulation of superoxide anion generation • cell adhesion mediated by integrin • positive regulation of neutrophil degranulation • negative regulation of dopamine metabolic process • positive regulation of protein targeting to membrane • amyloid-beta clearance • cell-cell adhesion • cell-cell adhesion via plasma-membrane adhesion molecules • positive regulation of neuron death • positive regulation of microglial cell activation • neutrophil migration • positive regulation of prostaglandin-E synthase activity • positive regulation of leukocyte adhesion to vascular endothelial cell Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3689	16414
Ensembl	ENSG00000160255	ENSMUSG00000000290
UniProt	P05107	P11835
RefSeq (mRNK)	NM_000211 NM_001127491 NM_001303238	NM_008404
RefSeq (bjelančevina)	NP_000202 NP_001120963 NP_001290167	NP_032430
Lokacija (UCSC)	Chr 21: 44.89 – 44.93 Mb	Chr 10: 77.37 – 77.4 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Integrinski beta lanac-2 (CD18 ) jest protein integrinskog koji je kod ljudi kodiran genom ITGB2 sa hromosoma 21.^[5] Nakon vezivanja sa jednim od brojnih alfa lanaca, CD18 je sposoban da formira više heterodimera, koji imaju značajnu ulogu u ćelijskoj adheziji i signalizaciji ćelijske površine, kao i važnu ulogu u imunskim odgovorima.^[5][6] CD18 takođe postoji u rastvorljivim oblicima koji se vezuju za ligand. Nedostaci u ekspresiji CD18 mogu dovesti do poremećaja adhezije u cirkulirajućim bijelim krvnim zrncima kod ljudi, smanjujući sposobnost imunskog sistema da se bori protiv stranih antigena.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000160255 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000000290 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ ^{a b} Amin Aanout, M. (March 1, 1990). "Structure and Function of the Leukocyte Adhesion Molecules CD11/CD18". Blood. 75 (5): 1037–1050. doi:10.1182/blood.V75.5.1037.1037. PMID 1968349.
6. ^ "ITGB2 integrin subunit beta 2 [ Homo sapiens (human) ]".