CTCF

CTCF
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1X6H, 2CT1
Dynodwyr
Cyfenwau	CTCF, MRD21, CCCTC-binding factor, FAP108, CFAP108
Dynodwyr allanol	OMIM: 604167 HomoloGene: 4786 GeneCards: CTCF
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • GO:0001106 transcription corepressor activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • zinc ion binding; • metal ion binding; • chromatin insulator sequence binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001948, GO:0016582 protein binding; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • chromatin binding;
Cydrannau o'r gell	• nucleoplasm; • Cromosom; • nucleolus; • chromosome, centromeric region; • condensed chromosome; • cnewyllyn cell;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • regulation of gene expression, epigenetic; • regulation of centromeric sister chromatid cohesion; • chromosome segregation; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0045996 negative regulation of transcription, DNA-templated; • protein localization to chromosome, centromeric region; • negative regulation of cell population proliferation; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:1901313 positive regulation of gene expression; • DNA methylation; • regulation of gene expression by genetic imprinting; • maintenance of DNA methylation; • negative regulation of gene expression; • regulation of histone methylation; • regulation of histone acetylation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	10664
	n/a
	ENSG00000102974
	n/a
	P49711
	n/a
	NM_001191022; NM_006565; NM_001363916
	n/a
	NP_001177951; NP_006556; NP_001350845
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTCF yw CTCF a elwir hefyd yn CCCTC-binding factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q22.1.^[2]

[1] "Human PubMed Reference:".

[2] CTCF - Cronfa NCBI

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[2]