Caveolina-1

Caveolina-1
Identificadors
Àlies	CAV1 (HUGO), BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21, Caveolin 1
Identif. externs	OMIM: 601047   MGI: 102709   HomoloGene: 1330   GeneCards: CAV1   OMA: CAV1 - orthologs
Malalties relacionades genèticament
congenital generalized lipodystrophy type 3  [1]
Localització del gen (humà) Cromosoma: 7 (humà)[2] Banda 7q31.2 Inici 116.524.994 bp[2] Fi 116.561.179 bp[2]
Localització del gen (ratolí) Cromosoma: 6 (ratolí)[3] Banda 6|6 A2 Inici 17.306.334 bp[3] Fi 17.341.451 bp[3]
Patró d'expressió d'ARN Bgee humà ratolí (ortòleg) Més explicacions lower lobe of lung  parietal pleura  skin of hip  Articulació sinovial visceral pleura  teixit adipós greix subcutani right lung  vena cava tendó d'Aquil·les Més explicacions left lung lobe  right lung  teixit adipós blanc right lung lobe  endothelial cell of lymphatic vessel  carotid body  cordó umbilical greix subcutani teixit adipós marró atrioventricular valve  Més referències a dades d'expressió BioGPS Més referències a dades d'expressió
Ontologia genètica Funció molecular protein-macromolecule adaptor activity  transmembrane transporter binding  structural molecule activity  signaling receptor binding  nitric-oxide synthase binding  patched binding  enzyme binding  peptidase activator activity  unió proteica  molecular adaptor activity  protein kinase binding  ATPase binding  cholesterol binding  inward rectifier potassium channel inhibitor activity  unió de proteïnes idèntica  protein heterodimerization activity  protein-containing complex binding  Component cel·lular endocytic vesicle membrane  endosoma  membrana  focal adhesion  VCP-NPL4-UFD1 AAA ATPase complex  perinuclear region of cytoplasm  caveola  Cili  membrana plasmàtica apical  reticle endoplasmàtic  membrane raft  component integral de la membrana  aparell de Golgi  early endosome membrane  membrana plasmàtica  Intracel·lular  cell cortex  membrana del reticle endoplasmàtic  Golgi membrane  integral component of plasma membrane  acrosomal membrane  membrana plasmàtica basolateral  cytoplasmic vesicle  Lipid droplet  citoplasma  complex macromolecular  sarcolemma  Procés biològic caveolin-mediated endocytosis  positive regulation of calcium ion transport into cytosol  vasoconstricció  response to progesterone  negative regulation of protein binding  regulation of peptidase activity  protein localization to plasma membrane raft  mammary gland development  vasculogenesis  negative regulation of pinocytosis  response to ischemia  angiogènesi  apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  cholesterol homeostasis  triglyceride metabolic process  negative regulation of canonical Wnt signaling pathway  calcium ion transport  negative regulation of cell population proliferation  cellular response to transforming growth factor beta stimulus  positive regulation of toll-like receptor 3 signaling pathway  regulation of cytosolic calcium ion concentration  regulation of smooth muscle contraction  vesicle organization  negative regulation of peptidyl-tyrosine autophosphorylation  regulation of cardiac muscle cell action potential involved in regulation of contraction  negative regulation of transforming growth factor beta receptor signaling pathway  protein localization to basolateral plasma membrane  receptor internalization involved in canonical Wnt signaling pathway  regulation of membrane repolarization during action potential  positive regulation of peptidyl-serine phosphorylation  negative regulation of protein tyrosine kinase activity  regulation of entry of bacterium into host cell  negative regulation of MAP kinase activity  positive regulation of vasoconstriction  negative regulation of potassium ion transmembrane transport  lactància  receptor-mediated endocytosis of virus by host cell  regulation of blood coagulation  regulation of ventricular cardiac muscle cell action potential  protein homooligomerization  procés viral  positive regulation of intrinsic apoptotic signaling pathway  negative regulation of receptor signaling pathway via JAK-STAT  mammary gland involution  calcium ion homeostasis  negative regulation of necroptotic process  regulation of the force of heart contraction  lipid storage  nitric oxide homeostasis  membrane depolarization  negative regulation of cytokine-mediated signaling pathway  cellular calcium ion homeostasis  negative regulation of transcription by RNA polymerase II  response to estrogen  response to calcium ion  regulation of fatty acid metabolic process  cellular response to exogenous dsRNA  negative regulation of MAPK cascade  regulation of ruffle assembly  positive regulation of protein binding  positive regulation of protein ubiquitination  negative regulation of anoikis  leukocyte migration  protein localization  positive regulation of cell adhesion molecule production  response to hypoxia  negative regulation of nitric-oxide synthase activity  response to bacterium  caveola assembly  cellular response to hyperoxia  cholesterol transport  cellular response to starvation  T cell costimulation  regulation of nitric-oxide synthase activity  receptor internalization  positive regulation of peptidase activity  positive regulation of ER-associated ubiquitin-dependent protein catabolic process  negative regulation of endothelial cell proliferation  negative regulation of BMP signaling pathway  negative regulation of protein ubiquitination  cellular response to peptide hormone stimulus  positive regulation of gene expression  negative regulation of nitric oxide biosynthetic process  angiotensin-activated signaling pathway involved in heart process  protein complex oligomerization  negative regulation of peptidyl-serine phosphorylation  posttranscriptional regulation of gene expression  positive regulation of gap junction assembly  maintenance of protein location in cell  negative regulation of signal transduction  regulation of the force of heart contraction by chemical signal  regulation of cell communication by electrical coupling involved in cardiac conduction  regulation of heart rate by cardiac conduction  negative regulation of epithelial cell differentiation  skeletal muscle tissue development  beta-catenin destruction complex disassembly  positive regulation of catalytic activity  positive regulation of canonical Wnt signaling pathway  negative regulation of tyrosine phosphorylation of STAT protein  negative regulation of inward rectifier potassium channel activity  diferenciació cel·lular  positive regulation of cell migration  positive regulation of cold-induced thermogenesis  positive regulation of NF-kappaB transcription factor activity  Fonts: Amigo / QuickGO
Ortòlegs Espècies Humà Ratolí Entrez 857 12389 Ensembl ENSG00000105974 ENSMUSG00000007655 UniProt Q03135 P49817 RefSeq (ARNm) NM_001753 NM_001172895 NM_001172896 NM_001172897 NM_001243064 NM_007616 RefSeq (proteïna) NP_001166366 NP_001166367 NP_001166368 NP_001744 NP_001229993 NP_031642 Localització (UCSC) Chr 7: 116.52 – 116.56 Mb Chr 6: 17.31 – 17.34 Mb Cerca a PubMed [4] [5]
Wikidata
Veure/Editar gen humà Veure/Editar gen del ratolí

La caveolina-1 és una proteïna codificada pel gen CAV1 en humans. Tot i això, també pot estar present en altres animals com els ratolins (Mus musculus), els bous (Bos primigenius taurus) i els gossos (Canis lupus familiaris), entre molts altres.

Aquesta proteïna és el principal component de les caveoles, que es troben en les membranes plasmàtiques de la majoria de les cèl·lules.

El gen CAV1 juntament amb el CAV2 estan localitzats un al costat de l'altre en el cromosoma 7 en el cas dels humans. En els ratolins es troben en el cromosoma 6, en els bous es troben en el cromosoma 4 i en els gossos, en el 14.^[6][7][8][9]