Chlorambucil

Chlorambucil
Clinical data
Trade names	Leukeran, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682899
Routes of; administration	By mouth
ATC code	L01AA02 (WHO) ;
Legal status
Legal status	US: WARNING; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	?
Metabolism	Liver
Elimination half-life	1.5 hours
Excretion	N/A
Identifiers
	IUPAC name 4-[bis(2-chlorethyl)amino]benzenebutanoic acid;
CAS Number	305-03-3 ;
PubChem CID	2708;
IUPHAR/BPS	7143;
DrugBank	DB00291 ;
ChemSpider	2607 ;
UNII	18D0SL7309;
KEGG	D00266 ;
ChEBI	CHEBI:28830 ;
ChEMBL	ChEMBL515 ;
CompTox Dashboard (EPA)	DTXSID7020263 ;
ECHA InfoCard	100.005.603
Chemical and physical data
Formula	C14H19Cl2NO2
Molar mass	304.21 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClCCN(CCCl)c1ccc(cc1)CCCC(=O)O;
	InChI InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19) ; Key:JCKYGMPEJWAADB-UHFFFAOYSA-N ;
	(verify)

Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma.^[2] For CLL it is a preferred treatment.^[3] It is given by mouth.^[3]

Common side effects include bone marrow suppression.^[3] Other serious side effects include an increased long term risk of further cancer, infertility, and allergic reactions.^[3] Use during pregnancy often results in harm to the baby.^[3] Chlorambucil is in the alkylating agent family of medications.^[3] It works by blocking the formation of DNA and RNA.^[3]

Chlorambucil was approved for medical use in the United States in 1957.^[3] It is on the World Health Organization's List of Essential Medicines.^[4]^[5] It was originally made from nitrogen mustard.^[3]

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ "Chlorambucil". National Cancer Institute. 17 September 2014. Archived from the original on 21 December 2016. Retrieved 19 December 2016.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Chlorambucil". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.