Clusterin

CLU
Identifiers
Aliases	CLU, AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, clusterin
External IDs	OMIM: 185430; MGI: 88423; HomoloGene: 1382; GeneCards: CLU; OMA:CLU - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.1 Start 27,596,917 bp[1] End 27,614,700 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D1|14 34.36 cM Start 66,205,932 bp[2] End 66,218,996 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus Achilles tendon paraflocculus of cerebellum palpebral conjunctiva optic nerve Brodmann area 10 right uterine tube middle frontal gyrus Brodmann area 9 right testis Top expressed in iris ciliary body epithelium of lens habenula paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus Epithelium of choroid plexus dorsal tegmental nucleus subiculum ventral tegmental area More reference expression data BioGPS n/a
Gene ontology Molecular function chaperone binding misfolded protein binding ATPase activity protein binding ubiquitin protein ligase binding Cellular component cytoplasm apical dendrite cytosol Golgi apparatus blood microparticle mitochondrial membranes membrane extracellular matrix neurofibrillary tangle chromaffin granule spherical high-density lipoprotein particle extracellular region cell surface intracellular membrane-bounded organelle mitochondrion endoplasmic reticulum extracellular exosome platelet alpha granule lumen nucleus cytoplasmic vesicle intracellular anatomical structure perinuclear region of cytoplasm extracellular space Biological process apoptotic process central nervous system myelin maintenance negative regulation of protein homooligomerization response to misfolded protein chaperone-mediated protein complex assembly positive regulation of tau-protein kinase activity lipid metabolism immune system process negative regulation of amyloid-beta formation positive regulation of nitric oxide biosynthetic process complement activation response to virus protein stabilization platelet degranulation positive regulation of neuron death negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of neurofibrillary tangle assembly microglial cell activation protein import intrinsic apoptotic signaling pathway positive regulation of amyloid-beta formation regulation of neuronal signal transduction microglial cell proliferation positive regulation of NF-kappaB transcription factor activity positive regulation of ubiquitin-dependent protein catabolic process cell morphogenesis regulation of neuron death complement activation, classical pathway positive regulation of tumor necrosis factor production positive regulation of apoptotic process regulation of amyloid-beta clearance innate immune response positive regulation of intrinsic apoptotic signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process release of cytochrome c from mitochondria reverse cholesterol transport chaperone-mediated protein folding antimicrobial humoral response cell death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1191 12759 Ensembl ENSG00000120885 ENSMUSG00000022037 UniProt P10909 Q06890 RefSeq (mRNA) NM_001831 NM_013492 RefSeq (protein) NP_001822 NP_038520 Location (UCSC) Chr 8: 27.6 – 27.61 Mb Chr 14: 66.21 – 66.22 Mb PubMed search [3] [4]
Wikidata
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In humans, clusterin (CLU) is encoded by the CLU gene on chromosome 8.^[5] CLU is an extracellular molecular chaperone which binds to misfolded proteins in body fluids to neutralise their toxicity and mediate their cellular uptake by receptor-mediated endocytosis. Once internalised by cells, complexes between CLU and misfolded proteins are trafficked to lysosomes where they are degraded. ^[6] CLU is involved in many diseases including neurodegenerative diseases, cancers, inflammatory diseases, and aging.^[7][8][9]