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Decitabin

Decitabin
Klinički podaci
Drugs.comMonografija
Način primeneIntravenozno
Farmakokinetički podaci
Poluvreme eliminacije0,5 h
Identifikatori
CAS broj2353-33-5 ДаY
ATC kodNone
PubChemCID 451668
DrugBankDB01262 ДаY
ChemSpider397844 ДаY
ChEBICHEBI:50131 ДаY
ChEMBLCHEMBL1201129 ДаY
Hemijski podaci
FormulaC8H12N4O4
Molarna masa228,205
  • NC1=NC(=O)N(C=N1)[C@H]1C[C@H](O)[C@@H](CO)O1
  • InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1 ДаY
  • Key:XAUDJQYHKZQPEU-KVQBGUIXSA-N ДаY

Decitabin je organsko jedinjenje, koje sadrži 8 atoma ugljenika i ima molekulsku masu od 228,205 Da.[1][2][3][4][5][6][7][8][9]

  1. ^ Appleton K, Mackay HJ, Judson I, Plumb JA, McCormick C, Strathdee G, Lee C, Barrett S, Reade S, Jadayel D, Tang A, Bellenger K, Mackay L, Setanoians A, Schatzlein A, Twelves C, Kaye SB, Brown R: Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors. J Clin Oncol. 2007 Oct 10;25(29):4603-9. PMID 17925555
  2. ^ Wijermans PW, Ruter B, Baer MR, Slack JL, Hussain SI, Lubbert M: Efficacy of decitabine in the treatment of patients with chronic myelomonocytic leukemia (CMML). Leuk Res. 2007 Sep 17;. PMID 17881052
  3. ^ Daskalakis M, Blagitko-Dorfs N, Hackanson B: Decitabine. Recent Results Cancer Res. 2010;184:131-57. PMID 20072836
  4. ^ Saba HI, Wijermans PW: Decitabine in myelodysplastic syndromes. Semin Hematol. 2005 Jul;42(3 Suppl 2):S23-31. PMID 16015501
  5. ^ Jabbour E, Issa JP, Garcia-Manero G, Kantarjian H: Evolution of decitabine development: accomplishments, ongoing investigations, and future strategies. Cancer. 2008 Jun;112(11):2341-51. PMID 18398832
  6. ^ Stresemann C, Lyko F: Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine. Int J Cancer. 2008 Jul 1;123(1):8-13. PMID 18425818
  7. ^ Oki Y, Aoki E, Issa JP: Decitabine--bedside to bench. Crit Rev Oncol Hematol. 2007 Feb;61(2):140-52. Epub 2006 Oct 4. PMID 17023173
  8. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126.  уреди
  9. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958.  уреди

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ديسيتابين Arabic Decitabin German Decitabine English Decitabina Spanish Dezitabina EU Décitabine French ଡେସିଟାବାଇନ OR Decitabină Romanian Decitabin SH డెసిటాబైన్ Tegulu

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