ERAP1

ERAP1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2YD0, 3MDJ, 3QNF, 3RJO
Identifikatori
Aliasi	ERAP1
Vanjski ID-jevi	OMIM: 606832 MGI: 1933403 HomoloGene: 140581 GeneCards: ERAP1
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek)[1] Bend 5q15 Početak 96,760,810 bp[1] Kraj 96,808,100 bp[1]
Lokacija gena (miš) Hrom. Hromosom 13 (miš)[2] Bend 13|13 C1 Početak 74,787,687 bp[2] Kraj 74,841,320 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • interleukin-6 receptor binding • peptide binding • vezivanje iona cinka • vezivanje iona metala • interleukin-1, type II receptor binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 vezivanje za proteine • aminopeptidase activity • metalloexopeptidase activity • hydrolase activity • metallopeptidase activity • endopeptidase activity • metalloaminopeptidase activity Ćelijska komponenta • citoplazma • integral component of membrane • citosol • endoplasmic reticulum membrane • membrana • extracellular region • Endoplazmatski retikulum • Egzosom • Vanćelijsko • endoplasmic reticulum lumen • ćelijska membrana Biološki proces • regulation of innate immune response • adaptive immune response • response to bacterium • immune system process • antigen processing and presentation of peptide antigen via MHC class I • Proteoliza • positive regulation of angiogenesis • membrane protein ectodomain proteolysis • Angiogeneza • fat cell differentiation • peptide catabolic process • antigen processing and presentation of endogenous peptide antigen via MHC class I • regulation of blood pressure • GO:0072468 Transdukcija signala • cell-cell signaling Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	51752	80898
Ensembl	ENSG00000164307	ENSMUSG00000021583
UniProt	Q9NZ08	Q9EQH2
RefSeq (mRNK)	NM_001040458 NM_001198541 NM_016442 NM_001349244	NM_030711
RefSeq (bjelančevina)	NP_001035548 NP_001185470 NP_057526 NP_001336173	NP_109636
Lokacija (UCSC)	Chr 5: 96.76 – 96.81 Mb	Chr 13: 74.79 – 74.84 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminopeptidazni regulator tipa 1 receptorskog faktora tumorske necroze, znan i kao endoplazmatskoretikulumska aminopeptidaza 1 (ARTS-1), jest protein koji je kod ljudi kodiran genom ARTS-1.^[5]

Endoplazmatskoretikulumska aminopeptidaza 1 je aktivna u endoplazmatskom retikulumu, koji je uključen u obradu i transport proteina. Ovaj protein je aminopeptidaza, enzim koji cijepa peptide na N-terminalu na manje fragmente koji se nazivaju aminokiseline.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000164307 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000021583 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ EntrezGene 51752