Fibronektina

FN1
Egitura erabilgarria PDB Ortologoaren bilaketa: H0Y7Z1%20or%20B7ZLE5 PDBe H0Y7Z1,B7ZLE5 RCSB PDB ID kodeen zerrenda 1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6, 1TTF, 1TTG, 2CG6, 2CG7, 2CK2, 2CKU, 2EC3, 2FN2, 2FNB, 2GEE, 2H41, 2H45, 2HA1, 2OCF, 2RKY, 2RKZ, 2RL0, 3CAL, 3EJH, 3GXE, 3M7P, 3MQL, 3R8Q, 3ZRZ, 4GH7, 4JE4, 4JEG, 4LXO, 4MMX, 4MMY, 4MMZ, 4PZ5, 2N1K, 5DC4, 5DC0, 5DC9, 3T1W
Identifikatzaileak
Aliasak	FN1 (HUGO), CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF
Kanpoko IDak	OMIM: 135600   MGI: 95566   HomoloGene: 1533   GeneCards: FN1   OMA: FN1 - orthologs
Genetikoki lotutako gaixotasunak
spondylometaphyseal dysplasia, 'corner fracture' type  [1]
Genearen kokapena (gizakia) Kromosoma: 2 (gizakia)[2] Banda 2q35 Hasiera 215.360.440 bp[2] Amaiera 215.436.073 bp[2]
Genearen kokapena (sagua) Kromosoma: 1 (sagua)[3] Banda 1 C3|1 36.05 cM Hasiera 71.624.679 bp[3] Amaiera 71.692.359 bp[3]
RNA adierazpen eredua Bgee gizakia sagua (ortholog) Adierazpen ohikoena diartrosia right coronary artery  Dezidua Descending thoracic aorta  synovial membrane  ascending aorta  Berna-hezur tendon of biceps brachii  stromal cell of endometrium  left coronary artery  Adierazpen ohikoena Kalota stroma of bone marrow  tunica media of zone of aorta  Zilbor-heste left lung lobe  Orkatila tail of embryo  tibiofemoral joint  endothelial cell of lymphatic vessel  atrio Erreferentziazko adierazpen datu gehiago BioGPS Erreferentziazko adierazpen datu gehiago
Gene ontologia Funtzio molekularra heparin binding  collagen binding  integrin binding  proteina lotura  identical protein binding  peptidase activator activity  protease binding  Zelularen osagaia blood microparticle  Zelula kanpoko matrize  Fibrinogeno  zelulaz kanpoko eremu  basement membrane  apical plasma membrane  extracellular exosome  platelet alpha granule lumen  endoplasmic reticulum-Golgi intermediate compartment  extracellular fluid  Prozesu biologikoa regulation of protein phosphorylation  calcium-independent cell-matrix adhesion  endodermal cell differentiation  positive regulation of fibroblast proliferation  positive regulation of substrate-dependent cell migration, cell attachment to substrate  platelet degranulation  extracellular matrix disassembly  orbaintze  positive regulation of peptidase activity  peptide cross-linking  Atxikipen zelular  positive regulation of gene expression  acute-phase response  angiogenesis  positive regulation of cell population proliferation  regulation of cell shape  regulation of ERK1 and ERK2 cascade  cell-substrate junction assembly  substrate adhesion-dependent cell spreading  integrin activation  positive regulation of axon extension  cell-matrix adhesion  leukocyte migration  response to wounding  extracellular matrix organization  Iturburuak: : Amigo / QuickGO
Ortologoak Espeziea Gizakia Sagua Entrez 2335 14268 Ensembl ENSG00000115414 ENSMUSG00000026193 UniProt P02751 P11276 RefSeq (RNAm) NM_001306129 NM_001306130 NM_001306131 NM_001306132 NM_002026 NM_054034 NM_212474 NM_212475 NM_212476 NM_212478 NM_212482 NM_001365517 NM_001365518 NM_001365519 NM_001365520 NM_001365521 NM_001365522 NM_001365523 NM_001365524 NM_001276408 NM_001276409 NM_001276410 NM_001276411 NM_001276412 NM_001276413 NM_010233 RefSeq (proteina) NP_001293058 NP_001293059 NP_001293060 NP_001293061 NP_002017 NP_473375 NP_997639 NP_997641 NP_997643 NP_997647 NP_001352446 NP_001352447 NP_001352448 NP_001352449 NP_001352450 NP_001352451 NP_001352452 NP_001352453 NP_001293058.1 NP_001293059.1 NP_001293061.1 NP_001263337 NP_001263338 NP_001263339 NP_001263340 NP_001263341 NP_001263342 NP_034363 Kokapena (UCSC) Chr 2: 215.36 – 215.44 Mb Chr 1: 71.62 – 71.69 Mb PubMed bilaketa [4] [5]
Wikidata
Ikusi/Editatu giza genea Ikusi/Editatu saguaren genea

Fibronektina^[6] ornodun guztietan dagoen glukoproteina bat da. Fibronektina 440 kDa inguruko glukoproteina bat da, forma monomeriko edo dimerikoan ager daitekeena, eta animalia-ehun zelular gehienen zelula kanpoko matrizean dago. 20 isoforma ezberdin ere badaude. Fibronektina plasmatikoa deritzona, disolbagarria da eta odolean zirkulatzen du, non odolaren koagulazioa, orbaintzea eta fagozitosia areagotzen dituen.

1. ↑ Genetikoki lotutako gaixotasunak FN1ikusi/editatu erreferentziak Wikidatan. .
2. ↑ ^{a b c} GRCh38: Ensembl release 89: ENSG00000115414 - Ensembl, May 2017
3. ↑ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000026193 – Ensembl, May 2017
4. ↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. ↑ Euskalterm: [Immunologia Hiztegia] [2021]