GRIA4

GRIA4
Identifiers
Aliases	GRIA4, GLUR4, GLUR4C, GLURD, GluA4, glutamate ionotropic receptor AMPA type subunit 4, NEDSGA, GluA4-ATD
External IDs	OMIM: 138246; MGI: 95811; HomoloGene: 20227; GeneCards: GRIA4; OMA:GRIA4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q22.3 Start 105,609,994 bp[1] End 105,982,092 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A1|9 2.46 cM Start 4,417,896 bp[2] End 4,796,234 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum prefrontal cortex dorsolateral prefrontal cortex anterior cingulate cortex cerebellar vermis right frontal lobe Brodmann area 9 Pons C1 segment Top expressed in lobe of cerebellum cerebellar vermis dorsal tegmental nucleus anterior horn of spinal cord deep cerebellar nuclei dorsomedial hypothalamic nucleus medial geniculate nucleus ventral tegmental area medial vestibular nucleus lateral geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function ion channel activity ionotropic glutamate receptor activity extracellularly glutamate-gated ion channel activity excitatory extracellular ligand-gated ion channel activity AMPA glutamate receptor activity protein binding amyloid-beta binding signaling receptor activity Cellular component extracellular vesicle integral component of membrane endocytic vesicle membrane postsynaptic membrane cell projection membrane plasma membrane synapse cell junction dendrite AMPA glutamate receptor complex soma dendritic spine Biological process glutamate receptor signaling pathway ion transport ion transmembrane transport ionotropic glutamate receptor signaling pathway excitatory postsynaptic potential transport regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2893 14802 Ensembl ENSG00000152578 ENSMUSG00000025892 UniProt P48058 Q9Z2W8 RefSeq (mRNA) NM_000829 NM_001077243 NM_001077244 NM_001112812 NM_001113180 NM_001113181 NM_019691 RefSeq (protein) NP_000820 NP_001070711 NP_001070712 NP_001106283 NP_001106651 NP_001106652 NP_062665 Location (UCSC) Chr 11: 105.61 – 105.98 Mb Chr 9: 4.42 – 4.8 Mb PubMed search [3] [4]
Wikidata
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Glutamate receptor 4 is a protein that in humans is encoded by the GRIA4 gene.^[5]

This gene is a member of a family of L-glutamate-gated ion channels that mediate fast synaptic excitatory neurotransmission. These channels are also responsive to the glutamate agonist, alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate (AMPA). Some haplotypes of this gene show a positive association with schizophrenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[5] Like the other AMPA receptor subunits, GluA4 occurs as flip and flop spliced variant.^[6] In addition, GluA4 CTD long and short isoforms exist, and presumably an ATD-only isoform (433 aa).^[7]