Kalcitonin

CALCA
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2JXZ,%%s1LS7
Identifikatori
Aliasi	CALCA
Vanjski ID-jevi	OMIM: 114130 MGI: 2151253 HomoloGene: 88401 GeneCards: CALCA
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11p15.2 Početak 14,966,668 bp[1] Kraj 14,972,351 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7 F1|7 59.99 cM Početak 114,230,713 bp[2] Kraj 114,235,592 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • hormone activity • calcitonin receptor binding • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje identičnih proteina • signaling receptor binding • GO:0032403 protein-containing complex binding Ćelijska komponenta • citoplazma • intracellular anatomical structure • extracellular region • Akson • terminal bouton • soma • neuron projection • jedro • Vanćelijsko Biološki proces • cellular response to nerve growth factor stimulus • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • negative regulation of smooth muscle contraction • regulation of heart contraction • monocyte chemotaxis • negative regulation of blood pressure • positive regulation of cytosolic calcium ion concentration • cellular response to tumor necrosis factor • GO:0010260 starenje • Vazodilatacija • cellular calcium ion homeostasis • response to heat • negative regulation of nervous system process • positive regulation of ossification • activation of adenylate cyclase activity • regulation of heart rate • detection of temperature stimulus involved in sensory perception of pain • negative regulation of ossification • response to pain • artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure • ponašanje pri hranjenju • inflammatory response • neuropeptide signaling pathway • GO:0045996 negative regulation of transcription, DNA-templated • activation of protein kinase activity • embryo implantation • negative regulation of bone resorption • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytosolic calcium ion concentration • leukocyte cell-cell adhesion • G protein-coupled receptor internalization • positive regulation of interleukin-1 alpha production • response to yeast • negative regulation of osteoclast differentiation • cell-cell signaling • antibacterial humoral response • positive regulation of macrophage differentiation • receptor internalization • regulation of blood pressure • protein phosphorylation • vasculature development • GO:0051636 defense response to Gram-negative bacterium • endothelial cell proliferation • positive regulation of interleukin-8 production • nervous system process involved in regulation of systemic arterial blood pressure • negative regulation of calcium ion transport into cytosol • Urođeni imunski sistem • endothelial cell migration • antifungal humoral response • GO:0051637 defense response to Gram-positive bacterium • antimicrobial humoral immune response mediated by antimicrobial peptide • amylin receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	796	12310
Ensembl	ENSG00000110680	ENSMUSG00000030669
UniProt	P06881	P70160 Q99JA0
RefSeq (mRNK)	NM_001033952 NM_001033953 NM_001741 NM_001378949 NM_001378950	NM_001033954 NM_007587 NM_001289444 NM_001305616
RefSeq (bjelančevina)	NP_001029125.1	NP_001029126 NP_001276373 NP_001292545 NP_031613 NP_001029126.1 NP_001276373.1
Lokacija (UCSC)	Chr 11: 14.97 – 14.97 Mb	Chr 7: 114.23 – 114.24 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Kalcitonin je peptidni hormon od 32 aminokiseline, koga luče parafolikulskećelije (poznate i kao C-ćelije) tireoidne žlijezde kod čovjeka i mnogih drugih životnja, u ultimofarinsksnom tijelu.^[5] Djeluje na smanjenje kalcija u krvi (Ca^{2+ +}) suprotstavljajući se učincima paratireoidnog hormona (PTH).^[6]

Kalcitonin je nađen kod riba, gmizavaca, ptica i sisara]. Njegov značaj za ljude nije tako dobro utvrđen kao kod drugih životinja, jer njegova funkcija obično nije značajna u regulaciji normalnih homeostaza kalcija.^[7] Pripada porodici kalcitoninu-sličnih proteina.

Ranije se kalcitonin nazivao i tirokalcitonin.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000110680 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000030669 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Costoff A. "Sect. 5, Ch. 6: Anatomy, Structure, and Synthesis of Calcitonin (CT)". Endocrinology: hormonal control of calcium and phosphate. Medical College of Georgia. Arhivirano s originala, 5. 9. 2008. Pristupljeno 7. 8. 2008.
6. ^ Boron WF, Boulpaep EL (2004). "Endocrine system chapter". Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3. CS1 održavanje: nepreporučeni parametar (link)
7. ^ Costoff A. "Sect. 5, Ch. 6: Biological Actions of CT". Medical College of Georgia. Arhivirano s originala, 5. 7. 2008. Pristupljeno 7. 8. 2008.