Kaspaza-1

Kaspaza-1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7, 5FNA
Identifikatori
Aliasi	CASP1
Vanjski ID-jevi	OMIM: 147678 MGI: 96544 HomoloGene: 133272 GeneCards: CASP1
EC broj	3.4.22.36
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11q22.3 Početak 105,025,397 bp[1] Kraj 105,035,250 bp[1]
Lokacija gena (miš) Hrom. Hromosom 9 (miš)[2] Bend 9 A1|9 2.46 cM Početak 5,298,508 bp[2] Kraj 5,307,290 bp[2]
Ontologija gena Molekularna funkcija • cysteine-type peptidase activity • endopeptidase activity • GO:0070122 peptidase activity • GO:0001948, GO:0016582 vezivanje za proteine • cysteine-type endopeptidase activator activity involved in apoptotic process • hydrolase activity • cysteine-type endopeptidase activity involved in execution phase of apoptosis • cysteine-type endopeptidase activity involved in apoptotic process • kinase binding • cysteine-type endopeptidase activity • CARD domain binding • vezivanje identičnih proteina • cysteine-type endopeptidase activity involved in apoptotic signaling pathway Ćelijska komponenta • NLRP3 inflammasome complex • citoplazma • citosol • NLRP1 inflammasome complex • extracellular region • AIM2 inflammasome complex • mitohondrija • IPAF inflammasome complex • protease inhibitor complex • GO:0009327 makromolekulani kompleks Biološki proces • cellular response to organic substance • response to ATP • response to hypoxia • response to bacterium • membrane hyperpolarization • Piroptoza • protein processing • toxin transport • Proteoliza • cellular response to mechanical stimulus • response to lipopolysaccharide • regulation of autophagy • interleukin-1 beta production • mitochondrial depolarization • programmed necrotic cell death • GO:0072468 Transdukcija signala • GO:0097285 apoptoza • regulation of apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of inflammatory response • execution phase of apoptosis • cellular response to lipopolysaccharide • cellular response to interferon-gamma • protein autoprocessing • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • cytokine-mediated signaling pathway • cellular response to cytokine stimulus • apoptotic signaling pathway • positive regulation of interleukin-1 beta production Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	834	12362
Ensembl	ENSG00000137752	ENSMUSG00000025888
UniProt	P29466	P29452
RefSeq (mRNK)	NM_001223 NM_001257118 NM_001257119 NM_033292 NM_033293 NM_033294 NM_033295	NM_009807
RefSeq (bjelančevina)	NP_001214 NP_001244047 NP_001244048 NP_150634 NP_150635 NP_150636 NP_150637	NP_033937
Lokacija (UCSC)	Chr 11: 105.03 – 105.04 Mb	Chr 9: 5.3 – 5.31 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Kaspaza-1/Interleukin-1 pretvarajući enzim (ICE) je evolucijski konzervirani enzim koji proteolitski cijepa druge proteine, kao što su prekursori upalnih citokina interleukina-1β i interleukina-18, kao i induktora piroptoza gasdermina D, u aktivne zrele peptide. To jest enzim koji je kod ljudi kodiran genom CASP-1 sa hromosoma 11.^[5][6][7] Ima centralnu ulogu u ćelijskoj imunosti kao inicijator upalnog odgovora. [Jednom aktiviran kroz formiranje inflamasomskog kompleksa, on inicira proupalni odgovor kroz cijepanje i time aktiviranje dva upalna citokin, interleukin-1β (IL-1β) i interleukin-18 (IL-18) kao i piroptozu, programirani razgradni ćelijski smrtni put, cijepanjem gasdermina D.^[8] Dva upalna citokina aktivirana kaspazom-1 izlučuju se iz ćelije kako bi dalje izazvali upalni odgovor u susjednim ćelijama.^[9]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000137752 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000025888 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, et al. (april 1992). "A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes". Nature. 356 (6372): 768–74. Bibcode:1992Natur.356..768T. doi:10.1038/356768a0. PMID 1574116. S2CID 4310923.
6. ^ Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Van Ness K, Greenstreet TA, et al. (april 1992). "Molecular cloning of the interleukin-1 beta converting enzyme". Science. 256 (5053): 97–100. Bibcode:1992Sci...256...97C. doi:10.1126/science.1373520. PMID 1373520.
7. ^ Greška kod citiranja: Nevaljana oznaka <ref>; nije naveden tekst za reference s imenom pmid15190255
8. ^ Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, et al. (april 2021). "Gasdermin D pore structure reveals preferential release of mature interleukin-1". Nature. 593 (7860): 607–611. Bibcode:2021Natur.593..607X. doi:10.1038/s41586-021-03478-3. PMC 8588876 Provjerite vrijednost parametra |pmc= (pomoć). PMID 33883744. S2CID 233351704.
9. ^ Jorgensen I, Miao EA (maj 2015). "Pyroptotic cell death defends against intracellular pathogens". Immunological Reviews. 265 (1): 130–42. doi:10.1111/imr.12287. PMC 4400865. PMID 25879289.