LEP

LEP
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1AX8
Dynodwyr
Cyfenwau	LEP, LEPD, OB, OBS, leptin
Dynodwyr allanol	OMIM: 164160 HomoloGene: 193 GeneCards: LEP
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• hormone activity; • peptide hormone receptor binding; • signaling receptor binding;
Cydrannau o'r gell	• cytoplasm; • extracellular region; • extracellular space;
Prosesau biolegol	• regulation of protein phosphorylation; • response to dietary excess; • cellular response to retinoic acid; • positive regulation of developmental growth; • negative regulation of glucagon secretion; • placenta development; • cardiac muscle hypertrophy; • regulation of angiogenesis; • prostaglandin secretion; • regulation of intestinal cholesterol absorption; • T cell differentiation; • positive regulation of reactive oxygen species metabolic process; • central nervous system neuron development; • Rhythm circadaidd; • positive regulation of ion transport; • angiogenesis; • glucose metabolic process; • positive regulation of peroxisome proliferator activated receptor signaling pathway; • positive regulation of hepatic stellate cell activation; • regulation of endothelial cell proliferation; • intestinal absorption; • response to ethanol; • negative regulation of autophagy; • positive regulation of p38MAPK cascade; • positive regulation of protein kinase B signaling; • negative regulation of metabolic process; • negative regulation of vasoconstriction; • glucose homeostasis; • regulation of insulin secretion; • regulation of steroid biosynthetic process; • insulin secretion; • regulation of natural killer cell activation; • regulation of fat cell differentiation; • response to vitamin E; • response to nutrient levels; • bone mineralization involved in bone maturation; • positive regulation of T cell proliferation; • positive regulation of protein import into nucleus; • regulation of brown fat cell differentiation; • fatty acid beta-oxidation; • regulation of metabolic process; • hormone metabolic process; • positive regulation of MAPK cascade; • positive regulation of TOR signaling; • cellular response to L-ascorbic acid; • ovulation from ovarian follicle; • activation of protein kinase C activity; • atgynhyrchu rhywiol; • negative regulation of cartilage development; • response to nutrient; • negative regulation of glutamine transport; • leptin-mediated signaling pathway; • bile acid metabolic process; • female pregnancy; • negative regulation of apoptotic process; • cholesterol metabolic process; • positive regulation of follicle-stimulating hormone secretion; • GO:1901227 negative regulation of transcription by RNA polymerase II; • negative regulation of appetite; • regulation of protein localization to nucleus; • regulation of blood pressure; • negative regulation of glucose import; • leukocyte tethering or rolling; • negative regulation of lipid storage; • adipose tissue development; • GO:1903106 positive regulation of insulin receptor signaling pathway; • bone growth; • positive regulation of receptor signaling pathway via JAK-STAT; • glycerol biosynthetic process; • positive regulation of luteinizing hormone secretion; • fatty acid catabolic process; • regulation of gluconeogenesis; • response to estradiol; • GO:0007243 intracellular signal transduction; • adult feeding behavior; • response to hypoxia; • regulation of natural killer cell proliferation; • eating behavior; • GO:0032737 positive regulation of cytokine production; • regulation of cytokine production involved in inflammatory response; • regulation of nitric-oxide synthase activity; • response to activity; • cellular response to leptin stimulus; • regulation of cell cycle; • regulation of natural killer cell mediated cytotoxicity; • positive regulation of fat cell apoptotic process; • positive regulation of cell population proliferation; • regulation of lipoprotein lipid oxidation; • positive regulation of phosphatidylinositol 3-kinase signaling; • GO:0072468 signal transduction; • regulation of bone remodeling; • lipid metabolism; • negative regulation of appetite by leptin-mediated signaling pathway; • interleukin-12 production; • positive regulation of tumor necrosis factor production; • interleukin-6 production; • response to insulin; • tyrosine phosphorylation of STAT protein; • ffagocytosis; • energy reserve metabolic process; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • determination of adult lifespan; • regulation of lipid biosynthetic process; • positive regulation of cold-induced thermogenesis; • aorta development; • GO:0048552 regulation of catalytic activity; • elastin metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	3952
	n/a
	ENSG00000174697
	n/a
	P41159
	n/a
	NM_000230
	n/a
	NP_000221
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LEP yw LEP a elwir hefyd yn Leptin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q32.1.^[2]

[1] "Human PubMed Reference:".

[2] LEP - Cronfa NCBI

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[2]