MAPK1

MAPK1
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1PME, 1TVO, 1WZY, 2OJG, 2OJI, 2OJJ, 2Y9Q, 3D42, 3D44, 3I5Z, 3I60, 3SA0, 3TEI, 3W55, 4FMQ, 4FUX, 4FUY, 4FV0, 4FV1, 4FV2, 4FV3, 4FV4, 4FV5, 4FV6, 4FV7, 4FV8, 4FV9, 4G6N, 4G6O, 4H3P, 4H3Q, 4IZ5, 4IZ7, 4IZA, 4N0S, 4NIF, 4O6E, 4QTA, 4QTE, 4ZZM, 4ZZN, 4ZZO, 5BUE, 5BUI, 5BUJ, 4QP1, 4QP2, 4QP3, 4QP4, 4QP6, 4QP7, 4QP8, 4QP9, 4QPA, 4XJ0, 5BVD, 5BVE, 5BVF, 5AX3, 4ZXT, 5K4I
識別子
記号	MAPK1, ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK, mitogen-activated protein kinase 1, NS13
外部ID	OMIM: 176948 MGI: 1346858 HomoloGene: 37670 GeneCards: MAPK1
遺伝子の位置 (ヒト)
染色体	22番染色体 (ヒト)
終点	21,867,680 bp
遺伝子の位置 (マウス)
染色体	16番染色体 (マウス)
終点	16,865,317 bp
RNA発現パターン
	; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• phosphatase binding; • ATP binding; • protein kinase activity; • 転写因子結合; • トランスフェラーゼ活性; • mitogen-activated protein kinase kinase kinase binding; • phosphotyrosine residue binding; • 血漿タンパク結合; • プロテインキナーゼ結合; • DNA結合; • ヌクレオチド結合; • RNA polymerase II CTD heptapeptide repeat kinase activity; • protein serine/threonine kinase activity; • キナーゼ活性; • identical protein binding; • MAP kinase activity; • 二本鎖DNA結合; • MAP kinase kinase activity;
細胞の構成要素	• 細胞質; • 細胞質基質; • 焦点接着; • 微小管形成中心; • ミトコンドリア; • カベオラ; • dendrite cytoplasm; • 細胞骨格; • 細胞核; • エキソソーム; • 細胞体; • late endosome; • ゴルジ体; • 紡錘体; • 神経繊維; • early endosome; • mitotic spindle; • 仮足; • 細胞外領域; • 核質; • azurophil granule lumen; • ficolin-1-rich granule lumen; • 細胞膜; • シナプス後肥厚; • 膜; • 高分子複合体;
生物学的プロセス	• caveolin-mediated endocytosis; • positive regulation of telomere capping; • response to exogenous dsRNA; • cardiac neural crest cell development involved in heart development; • positive regulation of translation; • cellular response to DNA damage stimulus; • platelet activation; • Fc-epsilon receptor signaling pathway; • タンパク質リン酸化; • face development; • cellular response to granulocyte macrophage colony-stimulating factor stimulus; • regulation of DNA-binding transcription factor activity; • animal organ morphogenesis; • 細胞周期; • ERBB signaling pathway; • アポトーシス; • B cell receptor signaling pathway; • regulation of transcription, DNA-templated; • タンパク質安定性の制御; • Fc-gamma receptor signaling pathway involved in phagocytosis; • 胸腺発生; • negative regulation of cell differentiation; • ERK1 and ERK2 cascade; • labyrinthine layer blood vessel development; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • 心臓発生; • viral process; • 毒性物質への反応; • regulation of stress-activated MAPK cascade; • 化学的シナプス伝達; • growth hormone receptor signaling pathway via JAK-STAT; • cytosine metabolic process; • リン酸化; • outer ear morphogenesis; • response to estrogen; • 走化性; • リポ多糖への反応; • 甲状腺発生; • response to epidermal growth factor; • positive regulation of telomerase activity; • 侵害受容; • peptidyl-threonine phosphorylation; • trachea formation; • リポ多糖を介したシグナル伝達経路; • mammary gland epithelial cell proliferation; • intracellular signal transduction; • lung morphogenesis; • neural crest cell development; • positive regulation of cell migration; • regulation of early endosome to late endosome transport; • ストレスへの反応; • positive regulation of telomere maintenance via telomerase; • MAPK cascade; • 軸索誘導; • fibroblast growth factor receptor signaling pathway; • positive regulation of peptidyl-threonine phosphorylation; • peptidyl-serine phosphorylation; • positive regulation of cell population proliferation; • regulation of cellular response to heat; • Bergmann glial cell differentiation; • regulation of Golgi inheritance; • T cell receptor signaling pathway; • regulation of cytoskeleton organization; • シグナル伝達; • 長期増強; • regulation of ossification; • regulation of phosphatidylinositol 3-kinase signaling; • 好中球脱顆粒; • 遺伝子発現調節; • 有機物への細胞応答; • 老化; • 学習と記憶; • positive regulation of gene expression; • diadenosine tetraphosphate biosynthetic process; • regulation of cellular pH; • cellular response to amino acid starvation; • cellular response to reactive oxygen species; • response to nicotine; • 脱落膜化; • stress-activated MAPK cascade; • positive regulation of cardiac muscle cell proliferation; • cellular response to cadmium ion; • cellular response to tumor necrosis factor; • cellular response to dopamine; • positive regulation of protein import into nucleus;
	出典:Amigo / QuickGO
オルソログ
	5594
	26413
	ENSG00000100030
	ENSMUSG00000063358
	P28482
	P63085
	NM_138957; NM_002745
	NM_001038663; NM_011949; NM_001357115; NM_028991
	NP_002736; NP_620407
	NP_001033752; NP_036079; NP_001344044
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

MAPK1（mitogen-activated protein kinase 1）またはERK2（extracellular signal-regulated kinase 2）は、ヒトではMAPK1遺伝子にコードされる酵素（プロテインキナーゼ）である^[5]。

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100030 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063358 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs”. Biochem. Biophys. Res. Commun. 182 (3): 1416–22. (February 1992). doi:10.1016/0006-291X(92)91891-S. PMID 1540184.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100030 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063358 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid1540184-5] “Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs”. Biochem. Biophys. Res. Commun. 182 (3): 1416–22. (February 1992). doi:10.1016/0006-291X(92)91891-S. PMID 1540184.

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