MTOR

MTOR
Estructures disponibles
PDB	Cerca ortòloga: PDBe RCSB
Llista de codis id de PDB
	4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 5FLC
Identificadors
Àlies	MTOR (HUGO), FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase
Identif. externs	OMIM: 601231 MGI: 1928394 HomoloGene: 3637 GeneCards: MTOR OMA: MTOR - orthologs
Malalties relacionades genèticament
	macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome , isolated focal cortical dysplasia type II
Dirigit pel fàrmac
	dactolisib , everolimús, ridaforolimus , temsirolimus , perhexiline , ridaforolimus , apitolisib , azd-8055 , indoximod , sapanisertib , omipalisib , vistusertib
Localització del gen (humà)
	Cromosoma: 1 (humà)
Fi	11.262.551 bp
Localització del gen (ratolí)
	Cromosoma: 4 (ratolí)
Fi	148.642.140 bp
Patró d'expressió d'ARN
	Més explicacions
	Gònada; ; right hemisphere of cerebellum ; ; left testis ; ; right testis ; ; múscul gastrocnemi; ; right frontal lobe ; ; muscle of thigh ; ; testicle; ; ventricular zone ; ; apex of heart ;
	Més explicacions
	espermàtida; ; espermatòcit; ; right kidney ; ; dentate gyrus of hippocampal formation granule cell ; ; superior frontal gyrus ; ; genital tubercle ; ; primary visual cortex ; ; muscle of thigh ; ; ventricular zone ; ; neural layer of retina ;
	Més referències a dades d'expressió
	Més referències a dades d'expressió
Ontologia genètica
Funció molecular	protein domain specific binding ; TFIIIC-class transcription factor complex binding ; kinase activity ; unió d'ATP ; protein serine/threonine kinase activity ; transferase activity ; ribosome binding ; unió proteica ; protein kinase binding ; unió de nucleòtids ; phosphoprotein binding ; protein kinase activity ; protein-containing complex binding ; unió de proteïnes idèntica ; translation regulator activity ;
Component cel·lular	citoplasma ; citosol ; phosphatidylinositol 3-kinase complex ; membrana ; mitocondri ; TORC1 complex ; organelle membrane ; complex macromolecular ; mitochondrial outer membrane ; reticle endoplasmàtic ; TORC2 complex ; aparell de Golgi ; intracellular membrane-bounded organelle ; nucleoplasma ; cos cel·lular neuronal ; PML body ; membrana del reticle endoplasmàtic ; Golgi membrane ; lysosomal membrane ; dendrita ; sistema endomembranós ; nucli cel·lular ; Lisosoma ; glutamatergic synapse ; postsynaptic cytosol ;
Procés biològic	germ cell development ; positive regulation of protein phosphorylation ; response to amino acid ; positive regulation of lipid biosynthetic process ; positive regulation of actin filament polymerization ; positive regulation of skeletal muscle hypertrophy ; positive regulation of granulosa cell proliferation ; regulation of carbohydrate utilization ; post-embryonic development ; positive regulation of dendritic spine development ; positive regulation of translation ; positive regulation of eating behavior ; protein phosphorylation ; mRNA stabilization ; cell projection organization ; regulation of glycogen biosynthetic process ; positive regulation of cell growth involved in cardiac muscle cell development ; positive regulation of neuron maturation ; positive regulation of glial cell proliferation ; cellular response to hypoxia ; negative regulation of cell size ; response to cocaine ; positive regulation of protein kinase B signaling ; cardiac muscle contraction ; maternal process involved in female pregnancy ; ruffle organization ; regulation of GTPase activity ; cardiac muscle cell development ; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ; regulation of membrane permeability ; response to insulin ; regulation of myelination ; regulation of fatty acid beta-oxidation ; regulation of osteoclast differentiation ; positive regulation of cholangiocyte proliferation ; regulation of protein kinase B signaling ; spinal cord development ; positive regulation of peptidyl-tyrosine phosphorylation ; comportament social ; protein autophosphorylation ; negative regulation of cholangiocyte apoptotic process ; regulation of brown fat cell differentiation ; regulation of protein kinase activity ; negative regulation of protein phosphorylation ; positive regulation of oligodendrocyte differentiation ; regulation of carbohydrate metabolic process ; regulation of actin cytoskeleton organization ; voluntary musculoskeletal movement ; fosforilació ; multicellular organism growth ; negative regulation of muscle atrophy ; cicatrització ; positive regulation of neurogenesis ; response to morphine ; positive regulation of sensory perception of pain ; catabolisme de les proteïnes ; 'de novo' pyrimidine nucleobase biosynthetic process ; cellular response to nutrient levels ; energy reserve metabolic process ; peptidyl-threonine phosphorylation ; positive regulation of transcription by RNA polymerase III ; positive regulation of smooth muscle cell proliferation ; visual learning ; positive regulation of myotube differentiation ; positive regulation of cell death ; positive regulation of endothelial cell proliferation ; negative regulation of iodide transmembrane transport ; cardiac muscle tissue development ; positive regulation of nitric oxide biosynthetic process ; regulation of response to food ; heart morphogenesis ; positive regulation of neuron death ; cardiac cell development ; negative regulation of protein ubiquitination ; brain development ; positive regulation of gene expression ; memòria a llarg termini ; heart valve morphogenesis ; peptidyl-serine phosphorylation ; positive regulation of neuron projection development ; regulation of cellular response to heat ; positive regulation of lamellipodium assembly ; positive regulation of stress fiber assembly ; transducció de senyal ; regulation of protein phosphorylation ; negative regulation of macroautophagy ; anoikis ; TOR signaling ; reparació de l'ADN ; regulation of cell size ; negative regulation of autophagy ; positive regulation of epithelial to mesenchymal transition ; regulation of macroautophagy ; cellular response to amino acid starvation ; positive regulation of keratinocyte migration ; cellular response to amino acid stimulus ; cellular response to leucine ; positive regulation of wound healing, spreading of epidermal cells ; cellular response to leucine starvation ; cellular response to starvation ; TORC1 signaling ; creixement ; regulation of cell growth ; response to nutrient ; activation of protein kinase B activity ; T-helper 1 cell lineage commitment ; response to activity ; positive regulation of phosphoprotein phosphatase activity ; negative regulation of calcineurin-NFAT signaling cascade ; regulation of translation at synapse, modulating synaptic transmission ; positive regulation of cytoplasmic translational initiation ; response to nutrient levels ;
	Fonts: Amigo / QuickGO
Ortòlegs
	2475
	56717
	ENSG00000198793
	ENSMUSG00000028991
	P42345
	Q9JLN9
	NM_004958; NM_001386500; NM_001386501
	NM_020009
	NP_004949
	NP_064393
	Wikidata
Veure/Editar gen humà	Veure/Editar gen del ratolí

Mammalian/mechanistic target of rapamycin (mTOR) és una serina/treonina quinasa que forma part de la família de proteïnes relacionades amb fosfatidilinositol 3-quinasa (PI3K) molt conservada en eucariotes. Es troba codificada pel gen MTOR.

mTOR és el component principal de dos complexos proteics diferents i interacciona amb una gran quantitat de proteïnes regulant diferents processos cel·lulars, relacionats amb el creixement i proliferació cel·lular.

↑ «Malalties que s'associen genèticament amb MTOR, vegeu/editeu les referències a wikidata».
↑ «Fàrmacs amb els quals interactuen físicament amb MTOR, vegeu/editeu les referències a wikidata».
↑ ^3,0 ^3,1 ^3,2 GRCh38: Ensembl release 89: ENSG00000198793 - Ensembl, May 2017
↑ ^4,0 ^4,1 ^4,2 GRCm38: Ensembl release 89: ENSMUSG00000028991 – Ensembl, May 2017
↑ «Human PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «Mouse PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[1] «Malalties que s'associen genèticament amb MTOR, vegeu/editeu les referències a wikidata».

[2] «Fàrmacs amb els quals interactuen físicament amb MTOR, vegeu/editeu les referències a wikidata».

[refGRCh38Ensembl-3] 3,0 ^3,1 ^3,2 GRCh38: Ensembl release 89: ENSG00000198793 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4,0 ^4,1 ^4,2 GRCm38: Ensembl release 89: ENSMUSG00000028991 – Ensembl, May 2017

[5] «Human PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] «Mouse PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[1]

[2]

[3]

[4]

[5]

[6]

Our website is made possible by displaying online advertisements to our visitors. Please consider supporting us by disabling your ad blocker.

MTOR

Our website is made possible by displaying online advertisements to our visitors.
Please consider supporting us by disabling your ad blocker.