OPRM1

OPRM1
Identifikatori
Aliasi	OPRM1
Vanjski ID-jevi	OMIM: 600018 MGI: 97441 HomoloGene: 37368 GeneCards: OPRM1
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek)[1] Bend 6q25.2 Početak 154,010,496 bp[1] Kraj 154,246,867 bp[1]
Lokacija gena (miš) Hrom. Hromosom 10 (miš)[2] Bend 10 A1|10 1.85 cM Početak 6,708,506 bp[2] Kraj 6,988,198 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • voltage-gated calcium channel activity • morphine receptor activity • G protein-coupled receptor activity • neuropeptide binding • signal transducer activity • filamin binding • G protein-coupled opioid receptor activity • GO:0001948, GO:0016582 vezivanje za proteine • beta-endorphin receptor activity • G-protein alpha-subunit binding • protein C-terminus binding • protein domain specific binding • G-protein beta-subunit binding • peptide binding Ćelijska komponenta • postsynapse • citoplazma • integral component of membrane • perikaryon • Golđijev aparat • membrana • focal adhesion • integral component of plasma membrane • dendrite membrane • Endoplazmatski retikulum • neuron projection • Lipidni splav • Sarkolema • dendrite cytoplasm • ćelijska membrana • dendrit • endozom • Akson • projekcija ćelije • spine apparatus • integral component of postsynaptic membrane • integral component of presynaptic membrane Biološki proces • positive regulation of appetite • negative regulation of adenylate cyclase activity • adenylate cyclase-activating dopamine receptor signaling pathway • sensory perception • negative regulation of cAMP-mediated signaling • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • regulation of sensory perception of pain • eating behavior • locomotory behavior • estrous cycle • positive regulation of cytosolic calcium ion concentration • positive regulation of nitric oxide biosynthetic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of Wnt protein secretion • Zarastanje rana • acute inflammatory response to antigenic stimulus • positive regulation of cAMP-mediated signaling • positive regulation of neurogenesis • regulation of NMDA receptor activity • phospholipase C-activating G protein-coupled receptor signaling pathway • response to morphine • response to lipopolysaccharide • negative regulation of nitric oxide biosynthetic process • calcium ion transmembrane transport • excitatory postsynaptic potential • positive regulation of ERK1 and ERK2 cascade • behavioral response to ethanol • response to food • Nocicepcija • response to radiation • response to growth factor • response to ethanol • GO:0072468 Transdukcija signala • negative regulation of cell population proliferation • negative regulation of cytosolic calcium ion concentration • adenylate cyclase-inhibiting opioid receptor signaling pathway • response to cocaine • cellular response to morphine • chemical synaptic transmission • neuropeptide signaling pathway • G protein-coupled opioid receptor signaling pathway • G protein-coupled receptor signaling pathway • cytokine-mediated signaling pathway • GO:1904490 regulation of cellular response to stress • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	4988	18390
Ensembl	ENSG00000112038	ENSMUSG00000000766
UniProt	P35372	P42866
RefSeq (mRNK)	NM_000914 NM_001008503 NM_001008504 NM_001008505 NM_001145279 NM_001145280 NM_001145281 NM_001145282 NM_001145283 NM_001145284 NM_001145285 NM_001145286 NM_001145287 NM_001285522 NM_001285523 NM_001285524 NM_001285526 NM_001285527 NM_001285528	NM_001039652 NM_011013 NM_001302793 NM_001302794 NM_001302795 NM_001302796 NM_001304937 NM_001304938 NM_001304948 NM_001304950 NM_001304955
RefSeq (bjelančevina)	NP_000905 NP_001008503 NP_001008504 NP_001008505 NP_001138751 NP_001138752 NP_001138753 NP_001138754 NP_001138755 NP_001138756 NP_001138757 NP_001138758 NP_001138759 NP_001272451 NP_001272452 NP_001272453 NP_001272455 NP_001272456 NP_001272457	NP_001034741 NP_001289722 NP_001289723 NP_001289724 NP_001289725 NP_001291866 NP_001291867 NP_001291877 NP_001291879 NP_001291884
Lokacija (UCSC)	Chr 6: 154.01 – 154.25 Mb	Chr 10: 6.71 – 6.99 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

μ-Opioidni receptori (MOR) jesu protein koji je kod ljudi kodiran genom MOR. To je klasa opioidnih receptora sa visokim afinitetom za encefaline i beta-endorfine, ali niskim afinitetom za dinorfine. Također se nazivaju μ (mu)-opioidni peptidni (MOP) receptori. Prototipni μ-opioidni receptorski agonist je morfij, primarni psihoaktivni alkaloid u opijumu. To je inhibitorni receptor vezan za G-protein koji aktivira podjedinicu G_i alfa, inhibirajući aktivnost adenilat-ciklaza, snižavajući cAMP.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000112038 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000000766 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Zhorov BS, Ananthanarayanan VS (mart 2000). "Homology models of mu-opioid receptor with organic and inorganic cations at conserved aspartates in the second and third transmembrane domains". Arch. Biochem. Biophys. 375 (1): 31–49. doi:10.1006/abbi.1999.1529. PMID 10683246.