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Obestatin

Preprohormon grelin/obestatina
NMR structura obestatina u SDS / DPC micelnom rastvoru.[1]
Identifikatori
Simbol GHRL
Entrez 51738
HUGO 18129
OMIM 605353
RefSeq NM_016362
UniProt Q9UBU3
Drugi podaci
Lokus Hromozom 3 p26-p25

Obestatin je putativni hormon koji se potencijalno proizvodi u ćelijama sluzokože želuca i tankih creva kod nekoliko sisara među kojima je čovek.[2] Obestatin je originalno bio identifikovan kao anoreksioni peptid, mada njegov uticaj na unos hrane ostaje kontroverzan.[3]

  1. PDB 2JSH; Scrima M, Campiglia P, Esposito C, Gomez-Monterrey I, Novellino E, D'Ursi AM (November 2007). „Obestatin conformational features: a strategy to unveil obestatin's biological role?”. Biochem. Biophys. Res. Commun. 363 (3): 500–5. DOI:10.1016/j.bbrc.2007.08.200. PMID 17904104. 
  2. Gourcerol G, St-Pierre DH, Taché Y (June 2007). „Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)?”. Regul. Pept. 141 (1-3): 1–7. DOI:10.1016/j.regpep.2006.12.023. PMID 17321609. 
  3. Hassouna R, Zizzari P, Tolle V (July 2010). „The ghrelin/obestatin balance in the physiological and pathological control of growth hormone secretion, body composition and food intake”. J. Neuroendocrinol. 22 (7): 793–804. DOI:10.1111/j.1365-2826.2010.02019.x. PMID 20456603. 

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