Polidocanol

Polidocanol
Clinical data
Other names	Polydocanol; Laureth 9; Macrogol lauryl ether; Lauromacrogol; PEG-9 lauryl alcohol; POE-9 lauryl alcohol; Dodecylpolyethyleneglycolether; Hydroxyl polyethoxy dodecane; Oxypolyethoxydodecane;
AHFS/Drugs.com	International Drug Names
Pregnancy; category	Topical: allowed; Injection: contraindication in months 1–3 and after week 36;
Routes of; administration	topical, subcutaneous injection
ATC code	C05BB02 (WHO) ;
Legal status
Legal status	CA: ℞-only; OTC (topical), Rx (injection);
Identifiers
	IUPAC name 3,6,9,12,15,18,21,24,27-nonaoxanonatriacontan-1-ol;
CAS Number	9002-92-0 ; 3055-99-0;
PubChem CID	656641;
DrugBank	DB06811 ;
ChemSpider	570993 ;
UNII	0AWH8BFG9A;
KEGG	D01993 ;
ChEMBL	ChEMBL1201751 ;
CompTox Dashboard (EPA)	DTXSID5039721 ;
ECHA InfoCard	100.019.351
Chemical and physical data
Formula	C30H62O10
Molar mass	582.816 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO;
	InChI InChI=1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3 ; Key:ONJQDTZCDSESIW-UHFFFAOYSA-N ;
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Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused by eczema and dry skin.^[2] It has also been used to treat varicose veins,^[3] hemangiomas, and vascular malformations.^[4] It is formed by the ethoxylation of dodecanol.

^ "Health Canada New Drug Authorizations: 2015 Highlights". Health Canada. 4 May 2016. Retrieved 7 April 2024.
^ "E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12.
^ Star P, Connor DE, Parsi K (April 2018). "Novel developments in foam sclerotherapy: Focus on Varithena (polidocanol endovenous microfoam) in the management of varicose veins". Phlebology. 33 (3): 150–162. doi:10.1177/0268355516687864. PMID 28166694.
^ Gao Z, Zhang Y, Li W, Shi C (January 2018). "Effectiveness and safety of polidocanol for the treatment of hemangiomas and vascular malformations: A meta-analysis". Dermatologic Therapy. 31 (1): e12568. doi:10.1111/dth.12568. PMID 29082587.

Clinical data

Other names	Polydocanol Laureth 9 Macrogol lauryl ether Lauromacrogol PEG-9 lauryl alcohol POE-9 lauryl alcohol Dodecylpolyethyleneglycolether Hydroxyl polyethoxy dodecane Oxypolyethoxydodecane
AHFS/Drugs.com	International Drug Names
Pregnancy category	Topical: allowed Injection: contraindication in months 1–3 and after week 36
Routes of administration	topical, subcutaneous injection
ATC code	C05BB02 (WHO)
Legal status
Legal status	CA: ℞-only^[1] OTC (topical), Rx (injection)
Identifiers
IUPAC name 3,6,9,12,15,18,21,24,27-nonaoxanonatriacontan-1-ol
CAS Number	9002-92-0^Y 3055-99-0
PubChem CID	656641
DrugBank	DB06811^Y
ChemSpider	570993^N
UNII	0AWH8BFG9A
KEGG	D01993^Y
ChEMBL	ChEMBL1201751^N
CompTox Dashboard (EPA)	DTXSID5039721
ECHA InfoCard	100.019.351
Chemical and physical data
Formula	C₃₀H₆₂O₁₀
Molar mass	582.816 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI InChI=1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3^N Key:ONJQDTZCDSESIW-UHFFFAOYSA-N^N
^NY (what is this?) (verify)