Renin

Renin
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4XX4, 1BBS, 1BIL, 1BIM, 1HRN, 1RNE, 2BKS, 2BKT, 2FS4, 2G1N, 2G1O, 2G1R, 2G1S, 2G1Y, 2G20, 2G21, 2G22, 2G24, 2G26, 2G27, 2I4Q, 2IKO, 2IKU, 2IL2, 2REN, 2V0Z, 2V10, 2V11, 2V12, 2V13, 2V16, 2X0B, 3D91, 3G6Z, 3G70, 3G72, 3GW5, 3K1W, 3KM4, 3O9L, 3OAD, 3OAG, 3OOT, 3OQF, 3OQK, 3OWN, 3Q3T, 3Q4B, 3Q5H, 3SFC, 3VCM, 3VSW, 3VSX, 3VUC, 3VYD, 3VYE, 3VYF, 4AMT, 4GJ5, 4GJ6, 4GJ7, 4GJ8, 4GJ9, 4GJA, 4GJB, 4GJC, 4GJD, 4PYV, 4Q1N, 4RYC, 4RYG, 4RZ1, 4S1G, 4XX3
Identifikatori
Aliasi	REN
Vanjski ID-jevi	OMIM: 179820 MGI: 97898 HomoloGene: 20151 GeneCards: REN
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1q32.1 Početak 204,154,819 bp[1] Kraj 204,190,324 bp[1]
Ontologija gena Molekularna funkcija • insulin-like growth factor receptor binding • aspartic-type endopeptidase activity • endopeptidase activity • GO:0070122 peptidase activity • signaling receptor binding • hydrolase activity • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • citoplazma • membrana • ćelijska membrana • intracellular anatomical structure • extracellular region • Vanćelijsko • apical part of cell Biološki proces • response to immobilization stress • regulation of blood volume by renin-angiotensin • male gonad development • regulation of MAPK cascade • Nefrogeneza • renin-angiotensin regulation of aldosterone production • cell maturation • amyloid-beta metabolic process • response to organic substance • angiotensin maturation • Proteoliza • mesonephros development • regulation of blood pressure • response to lipopolysaccharide • GO:0044257 protein catabolic process • drinking behavior • hormone-mediated signaling pathway • response to cGMP • response to cAMP Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	5972	19701
Ensembl	ENSG00000143839	ENSMUSG00000070645
UniProt	P00797	P06281
RefSeq (mRNK)	NM_000537	NM_031192
RefSeq (bjelančevina)	NP_000528	NP_112469
Lokacija (UCSC)	Chr 1: 204.15 – 204.19 Mb	n/a
PubMed pretraga	[2]	[3]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Renin ili angiotenzinogen je enzim koji učestvuje u tijelu kao renin-angiotenzin aldosteron (RAAS), poznat kao renin-angiotenzin aldosteronska osa, koja učestvuje u vanćelijskoj zapremini, formiranu od krvne plazme, limfne i međućelijske tečnosti i arterijske vazokonstrikcije. Tato regulira srednji arterijskog krvnog pritisna organizma.^{[4][5][6][7][8] [9][10][11]}

Renin se često nepravilno naziva hormonom iako nema perifernih receptora i ima enzimsku aktivnost kojom se hidrolizira angiotenzinogen u angiotenzin I.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000143839 - Ensembl, maj 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ Alberts B. (2002)ː Molecular biology of the cell Garland Science, New York, ISBN 0-8153-3218-1.
5. ^ Lindhorst T. (2007): Essentials of carbohydrate chemistry and biochemistry. Wiley-VCH, 3527315284}}
6. ^ Robyt F. (1997): Essentials of carbohydrate chemistry. Springer, ISBN 0387949518.
7. ^ Voet D., Voet J. (1995): Biochemistry, 2nd Ed. Wiley, http://www.wiley.com/college/math/chem/cg/sales/voet.html.
8. ^ Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
9. ^ Kapur Pojskić L., Ed. (2014): Uvod u genetičko inženjerstvo i biotehnologiju, 2. izdanje. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 978-9958-9344-8-3.
10. ^ Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.
11. ^ Nelson D. L., Cox M. M. (2013): Lehninger principles of biochemistry. W. H. Freeman and Co., ISBN 978-1-4641-0962-1.