Thyroxine

Thyroxine
Names
Other names
O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine, (-)-thyroxine, 3,3′,5,5′-tetraiodo-L-thyronine
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
EC Number
  • 206-088-9
UNII
  • InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)
    Key: XUIIKFGFIJCVMT-UHFFFAOYSA-N
  • C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
Properties
C15H11I4NO4
Molar mass 776.874 g·mol−1
Appearance white solid
Melting point 235-236
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Thyroxine, also known as T4, is a hormone produced by the thyroid gland. It is the primary form of thyroid hormone found in the blood and acts as a prohormone of the more active thyroid hormone, triiodothyronine (T3).[1] Thyroxine and its active metabolites are essential for regulating metabolic rate, supporting heart and muscle function, promoting brain development, and maintaining bone health.[2][3]

  1. ^ Li J, Bai L, Wei F, Wei M, Xiao Y, Yan W, et al. (2020). "Effect of Addition of Thyroxine in the Treatment of Graves' Disease: A Systematic Review". Frontiers in Endocrinology. 11: 560157. doi:10.3389/fendo.2020.560157. PMC 7868565. PMID 33569041.
  2. ^ Kim HY, Mohan S (June 2013). "Role and Mechanisms of Actions of Thyroid Hormone on the Skeletal Development". Bone Research. 1 (2): 146–161. doi:10.4248/BR201302004. PMC 4472099. PMID 26273499.
  3. ^ Mullur R, Liu YY, Brent GA (April 2014). "Thyroid hormone regulation of metabolism". Physiological Reviews. 94 (2): 355–82. doi:10.1152/physrev.00030.2013. PMC 4044302. PMID 24692351.

Thyroxine

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