10 results found for: “mitomycin_c”.

Request time (Page generated in 0.296 seconds.)

Mitomycin C

Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given intravenously to treat upper gastro-intestinal...

Last Update: 2021-02-23T20:32:20Z Word Count : 1366

View Page View Rich Text Page View Plain Text Page

Mitomycins

lavendulae. They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C, its international...

Last Update: 2021-01-19T12:59:01Z Word Count : 977

View Page View Rich Text Page View Plain Text Page

Glaucoma

Casuccio A, Di Pace F, Cagini C, Ferraro LL, Cillino G (March 2016). "Biodegradable collagen matrix implant versus mitomycin-C in trabeculectomy: five-year...

Last Update: 2021-04-01T04:23:27Z Word Count : 10135

View Page View Rich Text Page View Plain Text Page

Crosslinking of DNA

vitiligo. Mitomycin C (MMC) is from a class of antibiotics that are used broadly in chemotherapy, often with gastrointestinal related cancers. Mitomycin C can...

Last Update: 2020-12-05T08:44:06Z Word Count : 3431

View Page View Rich Text Page View Plain Text Page

Streptococcus pneumoniae

Competence in S. pneumoniae is induced by DNA-damaging agents such as mitomycin C, fluoroquinolone antibiotics (norfloxacin, levofloxacin and moxifloxacin)...

Last Update: 2021-03-20T07:02:55Z Word Count : 2462

View Page View Rich Text Page View Plain Text Page

Photorefractive keratectomy

growth factor (NGF) in combination with docosahexaenoic acid (DHA). Mitomycin C worsens post-surgical dry eye. PRK may be performed on one eye at a time...

Last Update: 2021-01-08T12:47:53Z Word Count : 2770

View Page View Rich Text Page View Plain Text Page

Fanconi anemia

are sensitive to drugs that treat cancer by DNA crosslinking, such as mitomycin C. The typical age of death was 30 years in 2000. FA occurs in about one...

Last Update: 2021-02-07T10:47:45Z Word Count : 3283

View Page View Rich Text Page View Plain Text Page

Pterygium (conjunctiva)

resulted in better vision or quality of life. The additional use of mitomycin C is of unclear effect. Radiotherapy has also been used in an attempt to...

Last Update: 2020-12-22T15:18:08Z Word Count : 2006

View Page View Rich Text Page View Plain Text Page

Thermophile

are exposed to the DNA damaging agents UV irradiation, bleomycin or mitomycin C, species-specific cellular aggregation is induced. In S. acidocaldarius...

Last Update: 2021-03-19T20:28:45Z Word Count : 954

View Page View Rich Text Page View Plain Text Page

Trabeculectomy

capsule and the wound bed is treated for several seconds to minutes with mitomycin C (MMC, 0.5–0.2 mg/ml) or 5-fluorouracil (5-FU, 50 mg/ml) soaked sponges...

Last Update: 2021-04-08T19:13:16Z Word Count : 1609

View Page View Rich Text Page View Plain Text Page

Main result

Mitomycin C

Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given intravenously to treat upper gastro-intestinal cancers (e.g. esophageal carcinoma), anal cancers, and breast cancers, as well as by bladder instillation for superficial bladder tumours. It causes delayed bone marrow toxicity and therefore it is usually administered at 6-weekly intervals. Prolonged use may result in permanent bone-marrow damage. It may also cause lung fibrosis and renal damage. Mitomycin C has also been used topically rather than intravenously in several areas. The first is cancers, particularly bladder cancers and intraperitoneal tumours. It is now well known that a single instillation of this agent within 6 hours of bladder tumor resection can prevent recurrence. The second is in eye surgery where mitomycin C 0.02% is applied topically to prevent scarring during glaucoma filtering surgery and to prevent haze after PRK or LASIK; mitomycin C has also been shown to reduce fibrosis in strabismus surgery. The third is in esophageal and tracheal stenosis where application of mitomycin C onto the mucosa immediately following dilatation will decrease re-stenosis by decreasing the production of fibroblasts and scar tissue. Mitomycin C is a potent DNA crosslinker. A single crosslink per genome has shown to be effective in killing bacteria. This is accomplished by reductive activation of mitomycin to form a mitosene, which reacts successively via N-alkylation of two DNA bases. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5'-CpG-3'. Potential bis-alkylating heterocyclic quinones were synthetised in order to explore their antitumoral activities by bioreductive alkylation. Mitomycin is also used as a chemotherapeutic agent in glaucoma surgery. In the bacterium Legionella pneumophila, mitomycin C induces competence, a condition necessary for the process of natural transformation that transfers DNA and promotes recombination between cells. Exposure of the fruitfly Drosophila melanogaster to mitomycin C increases recombination during meiosis, a key stage of the sexual cycle. It has been suggested that during sexual process in prokaryotes (transformation) and eukaryotes (meiosis) DNA cross-links and other damages introduced by mitomycin C may be removed by recombinational repair.Anticancer treatments with chemotherapeutic agents often impair brain cell function leading to memory loss and cognitive dysfunction. In order to understand the basis of these impairments, mice were treated with mitomycin C, a chemotherapeutic agent, and cells of the prefrontal cortex were examined. This treatment resulted in an increase of the oxidative DNA damage 8-oxo-dG, a decrease in the enzyme OGG1 that ordinarily repairs such damage and epigenetic alterations. These alterations at the DNA level may explain, at least in part, the impairments of cognitive function after chemotherapy.Mitomycin was discovered in the 1950s by Japanese scientists in cultures of the microorganism Streptomyces caespitosus.


Dodaje.pl - Ogłoszenia lokalne