10 results found for: “ras_protein”.

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Ras GTPase

Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein...

Last Update: 2020-12-01T23:07:10Z Word Count : 3280

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KRAS

KRAS gene provides instructions for making a protein called K-Ras, part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the...

Last Update: 2021-02-07T14:28:17Z Word Count : 4195

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HRAS

HRas is a small G protein in the Ras subfamily of the Ras superfamily of small GTPases. Once bound to Guanosine triphosphate, H-Ras will activate a Raf...

Last Update: 2021-01-30T02:52:51Z Word Count : 1325

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RAS p21 protein activator 1

RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal...

Last Update: 2021-01-02T03:19:00Z Word Count : 1590

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GTPase-activating protein

as RhoA, Rac1, and Rac2. The GAPs that act on small GTP-binding proteins of the Ras superfamily have conserved structures and use similar mechanisms...

Last Update: 2021-01-17T20:46:29Z Word Count : 2234

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MRAS

Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the MRAS gene on chromosome...

Last Update: 2020-12-14T17:48:41Z Word Count : 2570

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Oncogene

target protein. They can cause cancer by turning the receptor permanently on (constitutively), even without signals from outside the cell. Ras is a small...

Last Update: 2021-03-30T02:39:10Z Word Count : 2123

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MAPK/ERK pathway

The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the...

Last Update: 2020-12-20T03:19:16Z Word Count : 2645

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Farnesyltransferase inhibitor

drugs that target protein farnesyltransferase with the downstream effect of preventing the proper functioning of the Ras (protein), which is commonly...

Last Update: 2020-12-05T17:55:21Z Word Count : 1079

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SYNGAP1

Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded by the SYNGAP1 gene. SYNGAP1...

Last Update: 2020-12-14T01:13:58Z Word Count : 2241

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Main result

Ras GTPase

Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. Mutations in ras genes can lead to the production of permanently activated Ras proteins. As a result, this can cause unintended and overactive signaling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRas, KRas, and NRas) are the most common oncogenes in human cancer; mutations that permanently activate Ras are found in 20% to 25% of all human tumors and up to 90% in certain types of cancer (e.g., pancreatic cancer). For this reason, Ras inhibitors are being studied as a treatment for cancer and other diseases with Ras overexpression.


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