Isoniazid

Isoniazid
Clinical data
Trade names	Hydra, Hyzyd, Isovit, others
Other names	isonicotinic acid hydrazide, isonicotinyl hydrazine, INH, INAH, INHA
AHFS/Drugs.com	Monograph
MedlinePlus	a682401
License data	US DailyMed: Isoniazid;
Pregnancy; category	AU: A; ;
Routes of; administration	By mouth, intramuscular, intravenous
ATC code	J04AC01 (WHO) J04AC51 (WHO), J04AM01 (WHO), J04AM02 (WHO), J04AM03 (WHO), J04AM04 (WHO), J04AM05 (WHO), J04AM06 (WHO), J04AM07 (WHO), J04AM08 (WHO), J04AM09 (WHO), J04AM12 (WHO);
Legal status
Legal status	CA: ℞-only; US: WARNINGRx-only;
Pharmacokinetic data
Protein binding	Very low (0–10%)
Metabolism	liver; CYP450: 2C19, 3A4 inhibitor
Elimination half-life	0.5–1.6h (fast acetylators), 2-5h (slow acetylators)
Excretion	urine (primarily), feces
Identifiers
	IUPAC name Pyridine-4-carbohydrazide;
CAS Number	54-85-3 ;
PubChem CID	3767;
DrugBank	DB00951 ;
ChemSpider	3635 ;
UNII	V83O1VOZ8L;
KEGG	D00346 ; C07054 ;
ChEBI	CHEBI:6030 ;
ChEMBL	ChEMBL64 ;
NIAID ChemDB	007657;
CompTox Dashboard (EPA)	DTXSID8020755 ;
ECHA InfoCard	100.000.195
Chemical and physical data
Formula	C6H7N3O
Molar mass	137.142 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CN=CC=C1C(=O)NN;
	InChI InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10) ; Key:QRXWMOHMRWLFEY-UHFFFAOYSA-N ;
	(verify)

Isoniazid, also known as isonicotinic acid hydrazide (INH), is an antibiotic used for the treatment of tuberculosis.^[4] For active tuberculosis, it is often used together with rifampicin, pyrazinamide, and either streptomycin or ethambutol.^[5] For latent tuberculosis, it is often used alone.^[4] It may also be used for atypical types of mycobacteria, such as M. avium, M. kansasii, and M. xenopi.^[4] It is usually taken by mouth, but may be used by injection into muscle.^[4]

^ "Isoniazid (Nydrazid) Use During Pregnancy". Drugs.com. 7 October 2019. Retrieved 24 January 2020.
^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ "Drug and medical device highlights 2018: Helping you maintain and improve your health". Health Canada. 14 October 2020. Retrieved 17 April 2024.
^ ^a ^b ^c ^d "Isoniazid". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 136. hdl:10665/44053. ISBN 9789241547659.