A granule is a large particle or grain. It can refer to:
- Granule (cell biology), any of several submicroscopic structures, some with explicable origins, others noted only as cell type-specific features of unknown function
- Astrophysics and geology:
- Granule (solar physics), a visible structure in the photosphere of the Sun arising from activity in the Sun's convective zone
- Martian spherules, spherical granules of material found on the surface of the planet Mars
- Granule (geology), a specified particle size of 2–4 millimetres (-1 to -2 on the φ scale)
- Granule, in pharmaceutical terms, small particles gathered into a larger, permanent aggregate in which the original particles can still be identified
- Granule (Oracle DBMS), a unit of contiguously allocated virtual memory
- Granular synthesis of sound