Receptor vitamina D

VDR
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1DB1, 1IE8, 1IE9, 1KB2, 1KB4, 1KB6, 1S0Z, 1S19, 1TXI, 1YNW, 2HAM, 2HAR, 2HAS, 2HB7, 2HB8, 3A2I, 3A2J, 3A3Z, 3A40, 3A78, 3AUQ, 3AUR, 3AX8, 3AZ1, 3AZ2, 3AZ3, 3B0T, 3CS4, 3CS6, 3KPZ, 3M7R, 3OGT, 3P8X, 3TKC, 3VHW, 4G2I, 3W0A, 3W0C, 3W0Y, 3WGP, 3WWR, 4ITE, 4ITF, 4PA2, 3X31, 3X36, 4FHH, 4FHI, 2HBH
Identifikatori
Aliasi	VDR, NR1I1, PPP1R163, receptor vitamina D (1,25- dihidroksivitamin D3), receptor vitamina D
Vanjski ID-jevi	OMIM: 601769 MGI: 103076 HomoloGene: 37297 GeneCards: VDR
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek)[1] Bend 12q13.11 Početak 47,841,537 bp[1] Kraj 47,943,048 bp[1]
Lokacija gena (miš) Hrom. Hromosom 15 (miš)[2] Bend 15|15 F1 Početak 97,752,306 bp[2] Kraj 97,808,511 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • lithocholic acid binding • sequence-specific DNA binding • vezivanje sa DNK • lithocholic acid receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • steroid hormone receptor activity • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vezivanje iona cinka • vezivanje iona metala • vitamin D response element binding • retinoid X receptor binding • calcitriol binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • vitamin D binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity Ćelijska komponenta • jedro • nukleoplazma • receptor complex • RNA polymerase II transcription regulator complex • citoplazma Biološki proces • negative regulation of cell population proliferation • positive regulation of apoptotic process involved in mammary gland involution • positive regulation of keratinocyte differentiation • regulation of calcidiol 1-monooxygenase activity • intestinal absorption • calcium ion transport • steroid hormone mediated signaling pathway • GO:0009373 regulation of transcription, DNA-templated • lactation • bile acid signaling pathway • animal organ morphogenesis • GO:0000767 cell morphogenesis • skeletal system development • GO:1901313 positive regulation of gene expression • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • multicellular organism development • negative regulation of keratinocyte proliferation • decidualization • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0045996 negative regulation of transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • positive regulation of vitamin D 24-hydroxylase activity • mammary gland branching involved in pregnancy • GO:0072468 Transdukcija signala • cellular calcium ion homeostasis • transcription, DNA-templated • vitamin D receptor signaling pathway • vitamin D metabolic process • Ćelijska diferencijacija • intracellular receptor signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7421	22337
Ensembl	ENSG00000111424	ENSMUSG00000022479
UniProt	P11473	P48281
RefSeq (mRNK)	NM_000376 NM_001017535 NM_001017536 NM_001364085 NM_001374661 NM_001374662	NM_009504
RefSeq (bjelančevina)	NP_000367 NP_001017535 NP_001017536 NP_001351014 NP_001361590 NP_001361591	NP_033530
Lokacija (UCSC)	Chr 12: 47.84 – 47.94 Mb	Chr 15: 97.75 – 97.81 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Receptor kalcitriola – poznat i kao receptor vitamina D (VDR) i NR1 I 1 (potporodica nuklearnih receptora 1, grupa I, član 1) – je član porodice nuklearnih receptora transkripcijskih faktora.^[5] Nakon aktivacije vitamina D, VDR formira heterodimer sa retinoidnim X receptorom i veže sa elementima hormonskog odgovora na DNK. To rezultira u ispoljavanju ili transrepresiji specifičnih genskih proizvoda. VDR-i ne reguliraju samo transkripcijski odgovor, već su uključeni i u posttranskripcijske mehanizme koje usmjerava mikroRNK.^[6] Kod ljudi, receptor vitamina D je kodiran genom VDR.^[7]

Glukokortikoidi su poznati po smanjivanju ekspresije VDR, što se ispoljava u većini tkiva, a u probavnom traktu regulira transport kalcija, željeza i ostalih minerala.^[8]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000111424 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000022479 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA (decembar 2006). "International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor". Pharmacol. Rev. 58 (4): 742–59. doi:10.1124/pr.58.4.6. PMID 17132852.CS1 održavanje: upotreba parametra authors (link)
6. ^ Lisse TS, Chun RF, Rieger S, Adams JS, Hewison M (juni 2013). "Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts". J Bone Miner Res. 28 (6): 1478–14788. doi:10.1002/jbmr.1882. PMID 23362149.CS1 održavanje: upotreba parametra authors (link)
7. ^ Szpirer J, Szpirer C, Riviere M, Levan G, Marynen P, Cassiman JJ, Wiese R, DeLuca HF (septembar 1991). "The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7". Genomics. 11 (1): 168–73. doi:10.1016/0888-7543(91)90114-T. PMID 1662663.CS1 održavanje: upotreba parametra authors (link)
8. ^ Fleet JC, Schoch RD (august 2010). "Molecular Mechanisms for Regulation of Intestinal Calcium Absorption by Vitamin D and Other Factors". Crit Rev Clin Lab Sci. 47 (4): 181–195. doi:10.3109/10408363.2010.536429. PMID 21182397.CS1 održavanje: upotreba parametra authors (link)