Trombin

Trombin
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1A2C, 1A3B, 1A3E, 1ABI, 1ABJ, 1AD8, 1AE8, 1AI8, 1AIX, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD, 1DX5, 1E0F, 1EB1, 1EOJ, 1EOL, 1FPC, 1G30, 1G32, 1G37, 1GHV, 1GHW, 1GHX, 1GHY, 1GJ4, 1GJ5, 1H8D, 1H8I, 1HAI, 1HAO, 1HAP, 1HBT, 1HLT, 1HUT, 1HXE, 1HXF, 1IHS, 1JMO, 1JOU, 1JWT, 1K21, 1K22, 1KTS, 1KTT, 1LHC, 1LHD, 1LHE, 1LHF, 1LHG, 1MH0, 1MU6, 1MU8, 1MUE, 1NM6, 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 1NRS, 1NT1, 1NU7, 1NU9, 1NY2, 1NZQ, 1O0D, 1O2G, 1O5G, 1OOK, 1OYT, 1P8V, 1PPB, 1QBV, 1QHR, 1QJ1, 1QJ6, 1QJ7, 1QUR, 1RD3, 1RIW, 1SB1, 1SFQ, 1SG8, 1SGI, 1SHH, 1SL3, 1SR5, 1T4U, 1T4V, 1TA2, 1TA6, 1TB6, 1THP, 1THR, 1THS, 1TMB, 1TMU, 1TOM, 1TQ0, 1TQ7, 1TWX, 1UVS, 1VR1, 1VZQ, 1W7G, 1WAY, 1WBG, 1XM1, 1XMN, 1YPE, 1YPG, 1YPJ, 1YPK, 1YPL, 1YPM, 1Z71, 1Z8I, 1Z8J, 1ZGI, 1ZGV, 1ZRB, 2A0Q, 2A2X, 2A45, 2AFQ, 2ANK, 2ANM, 2B5T, 2BDY, 2BVR, 2BVS, 2BVX, 2BXT, 2BXU, 2C8Y, 2FEQ, 2FES, 2GDE, 2GP9, 2H9T, 2HGT, 2HNT, 2HPP, 2HPQ, 2HWL, 2JH0, 2JH6, 2OD3, 2PGB, 2PGQ, 2PW8, 2R2M, 2THF, 2ZFQ, 2ZFR, 2ZG0, 2ZHE, 2ZHF, 2ZHW, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 3B23, 3B9F, 3BEF, 3BEI, 3BF6, 3BIU, 3BIV, 3BV9, 3C1K, 3C27, 3D49, 3DA9, 3DD2, 3DT0, 3DUX, 3E6P, 3EE0, 3EQ0, 3F68, 3GIC, 3GIS, 3HAT, 3HKJ, 3HTC, 3JZ2, 3LDX, 3LU9, 3NXP, 3P17, 3P6Z, 3P70, 3PO1, 3QGN, 3QLP, 3QTO, 3QTV, 3QWC, 3QX5, 3R3G, 3RLW, 3RLY, 3RM0, 3RM2, 3RML, 3RMM, 3RMN, 3RMO, 3S7H, 3S7K, 3SHA, 3SHC, 3SI3, 3SI4, 3SQE, 3SQH, 3SV2, 3T5F, 3TU7, 3U69, 3U8O, 3U8R, 3U8T, 3U98, 3U9A, 3UTU, 3UWJ, 3VXE, 3VXF, 4BAH, 4BAK, 4BAM, 4BAN, 4BAO, 4BAQ, 4BOH, 4DIH, 4DII, 4DT7, 4DY7, 4E05, 4E06, 4E7R, 4H6S, 4H6T, 4HFP, 4HTC, 4THN, 5GDS, 7KME, 8KME, 1A46, 1A4W, 1A5G, 1A61, 1AFE, 1AHT, 1DWE, 1FPH, 1HAG, 1HAH, 1HDT, 1HGT, 1IHT, 1NO9, 1TBZ, 1TMT, 1UMA, 2C8W, 2C8X, 2C8Z, 2C90, 2C93, 2CF8, 2CF9, 2CN0, 2JH5, 2PKS, 2UUF, 2UUJ, 2UUK, 2V3H, 2V3O, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZGB, 2ZGX, 2ZHQ, 3DHK, 3EGK, 3JZ1, 3K65, 3PMH, 3QDZ, 4AX9, 4AYV, 4AYY, 4AZ2, 4CH2, 4CH8, 4HZH, 4I7Y, 4LOY, 4LXB, 4LZ1, 4LZ4, 4MLF, 4N3L, 4NZE, 4NZQ, 4O03, 4RKJ, 4RKO, 4RN6, 4YES, 4UD9, 4UDW, 4UE7, 4UEH, 5AF9, 5AFY, 5AFZ, 5AHG, 5CMX, 4UFD, 5EDM, 5E8E, 5EDK, 4UFE, 4UFG, 4UFF, 5A2M, 5JDU
Identifikatori
Aliasi	F2
Vanjski ID-jevi	OMIM: 176930 MGI: 88380 HomoloGene: 426 GeneCards: F2
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11p11.2 Početak 46,719,196 bp[1] Kraj 46,739,506 bp[1]
Lokacija gena (miš) Hrom. Hromosom 2 (miš)[2] Bend 2 E1|2 50.63 cM Početak 91,455,665 bp[2] Kraj 91,466,759 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • calcium ion binding • signaling receptor binding • GO:0070122 peptidase activity • hydrolase activity • growth factor activity • serine-type peptidase activity • thrombospondin receptor activity • GO:0001948, GO:0016582 vezivanje za proteine • serine-type endopeptidase activity • lipopolysaccharide binding • heparin binding • GO:0010577 enzyme activator activity Ćelijska komponenta • Egzosom • blood microparticle • endoplasmic reticulum lumen • Golgi lumen • ćelijska membrana • extracellular region • Vanćelijsko • external side of plasma membrane • collagen-containing extracellular matrix Biološki proces • blood coagulation, intrinsic pathway • regulation of blood coagulation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of collagen biosynthetic process • multicellular organism development • peptidyl-glutamic acid carboxylation • acute-phase response • positive regulation of reactive oxygen species metabolic process • endoplasmic reticulum to Golgi vesicle-mediated transport • positive regulation of cell growth • cell surface receptor signaling pathway • Regulacija ekspresije gena • positive regulation of release of sequestered calcium ion into cytosol • positive regulation of cell population proliferation • leukocyte migration • negative regulation of fibrinolysis • positive regulation of blood coagulation • regulation of cytosolic calcium ion concentration • response to wounding • signal peptide processing • positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of cell shape • Hemostaza • negative regulation of proteolysis • negative regulation of platelet activation • negative regulation of astrocyte differentiation • positive regulation of protein phosphorylation • Fibrinoliza • Koagulacija (krv) • Proteoliza • platelet activation • positive regulation of protein localization to nucleus • positive regulation of lipid kinase activity • regulation of complement activation • antimicrobial humoral immune response mediated by antimicrobial peptide • negative regulation of cytokine production involved in inflammatory response • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • positive regulation of receptor signaling pathway via JAK-STAT • blood coagulation, fibrin clot formation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2147	14061
Ensembl	ENSG00000180210	ENSMUSG00000027249
UniProt	P00734	P19221
RefSeq (mRNK)	NM_000506 NM_001311257	NM_010168
RefSeq (bjelančevina)	NP_000497	NP_034298
Lokacija (UCSC)	Chr 11: 46.72 – 46.74 Mb	Chr 2: 91.46 – 91.47 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Trombin (EC 3.4.21.5, fibrinogenaza, trombaza, trombofort, trombin-C, tropostazin, aktivirani faktor zgrušavanja krvi II, faktor zgrušavanja krvi IIa, faktor IIa, E-trombin, beta-trombin, gama-trombin) jest serin-proteaza, enzim koji je kod ljudi kodiran genom F2 sa hromosoma 11.^[5][6] Protrombin (faktor zgrušavanja II) se proteolitski cijepa kako bi se formirao trombin u proces zgrušavanja. Trombin zauzvrat djeluje kao serinska proteaza koja pretvara rastvorljivi fibrinogen u netopive niti fibrina, katalizirajući i mnoge druge reakcije povezane sa koagulacijom.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000180210 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000027249 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (maj 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somatic Cell and Molecular Genetics. 13 (3): 285–92. doi:10.1007/BF01535211. PMID 3474786. S2CID 45686258.
6. ^ Degen SJ, Davie EW (septembar 1987). "Nucleotide sequence of the gene for human prothrombin". Biochemistry. 26 (19): 6165–77. doi:10.1021/bi00393a033. PMID 2825773.