Dronabinol

El dronabinol (INN), també conegut amb els noms comercials Marinol i Syndros, és un nom genèric per a la molècula de delta-9-tetrahidrocannabinol en el context farmacèutic. Té indicacions com a estimulant de la gana, antiemètic i calmant de l'apnea del son^[1] i està aprovat per la FDA com a segur i eficaç només per l'anorèxia induïda per VIH/sida i nàusees i vòmits induïts per la quimioteràpia.^[2]^[3]^[4]

El dronabinol és la forma enantiòmer constituent principal del psicoactiu, (−)-trans-Δ⁹-tetrahidrocannabinol, que es troba a cànnabis.^[5] El dronabinol no inclou cap altre tetrahidrocannabinol (THC) isòmers ni cap cannabidiol.

↑ Schütz, Sonja G.; Dunn, Abbey; Braley, Tiffany J.; Pitt, Bertram; Shelgikar, Anita V. «New frontiers in pharmacologic obstructive sleep apnea treatment: A narrative review». Sleep Medicine Reviews. Elsevier BV, vol. 57, 2021, pàg. 101473. DOI: 10.1016/j.smrv.2021.101473. ISSN: 1087-0792. PMID: 33853035. «"Initial rodent studies showed that injections of dronabinol, a synthetic form of delta-9-tetrahydrocannabinol, in the nodose ganglia suppressed serotonin induced reflex apneas and increased upper airway dilating muscle activity during sleep. Limited studies in humans with moderate-to-severe OSA have demonstrated significant reduction in AHI with dronabinol use."»
↑ «Marinol (Dronabinol)». US Food and Drug Administration, 01-09-2004. [Consulta: 14 gener 2018].
↑ «Cannabis and Cannabinoids». National Cancer Institute, 24-10-2011. [Consulta: 12 gener 2014].
↑ «A review of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced nausea and vomiting: a focus on pharmacokinetic variability and pharmacodynamics». Cancer Chemotherapy and Pharmacology, vol. 80, 3, 9-2017, pàg. 441–449. DOI: 10.1007/s00280-017-3387-5. PMC: 5573753. PMID: 28780725.
↑ «List of psychotropic substances under international control». International Narcotics Control Board. [Consulta: 25 abril 2018]. «This international non-proprietary name refers to only one of the stereochemical variants of delta-9-tetrahydrocannabinol, namely (−)-trans-delta-9-tetrahydrocannabinol»

[Schütz_2021-1] Schütz, Sonja G.; Dunn, Abbey; Braley, Tiffany J.; Pitt, Bertram; Shelgikar, Anita V. «New frontiers in pharmacologic obstructive sleep apnea treatment: A narrative review». Sleep Medicine Reviews. Elsevier BV, vol. 57, 2021, pàg. 101473. DOI: 10.1016/j.smrv.2021.101473. ISSN: 1087-0792. PMID: 33853035. «"Initial rodent studies showed that injections of dronabinol, a synthetic form of delta-9-tetrahydrocannabinol, in the nodose ganglia suppressed serotonin induced reflex apneas and increased upper airway dilating muscle activity during sleep. Limited studies in humans with moderate-to-severe OSA have demonstrated significant reduction in AHI with dronabinol use."»

[fda-2] «Marinol (Dronabinol)». US Food and Drug Administration, 01-09-2004. [Consulta: 14 gener 2018].

[3] «Cannabis and Cannabinoids». National Cancer Institute, 24-10-2011. [Consulta: 12 gener 2014].

[4] «A review of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced nausea and vomiting: a focus on pharmacokinetic variability and pharmacodynamics». Cancer Chemotherapy and Pharmacology, vol. 80, 3, 9-2017, pàg. 441–449. DOI: 10.1007/s00280-017-3387-5. PMC: 5573753. PMID: 28780725.

[5] «List of psychotropic substances under international control». International Narcotics Control Board. [Consulta: 25 abril 2018]. «This international non-proprietary name refers to only one of the stereochemical variants of delta-9-tetrahydrocannabinol, namely (−)-trans-delta-9-tetrahydrocannabinol»

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Dronabinol

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