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Antiserum
 | This article may require cleanup to meet Wikipedia's quality standards. The specific problem is: Dives too deep into monoclonal, which mostly isn’t produced by live humans (or domestic animals) donating their serum, even in "modern use"! Antiserum needs to be serum or derived from it. (January 2023) |
In immunology, antiserum is a blood serum containing antibodies (either monoclonal or polyclonal) that is used to spread passive immunity to many diseases via blood donation (plasmapheresis). For example, convalescent serum, passive antibody transfusion from a previous human survivor, used to be the only known effective treatment for ebola infection with a high success rate of 7 out of 8 patients surviving.[1]
Antisera are widely used in diagnostic virology laboratories. The most common use of antiserum in humans is as antitoxin or antivenom to treat envenomation.[citation needed]
Serum therapy, also known as serotherapy, describes the treatment of infectious diseases using the serum of animals that have been immunized against the specific organism or components of that organism.[2][3]
- ^ Mupapa, K; Massamba, M; Kibadi, K; Kuvula, K; Bwaka, A; Kipasa, M; Colebunders, R; Muyembe-Tamfum, JJ (1999). "Treatment of Ebola Hemorrhagic Fever with Blood Transfusions from Convalescent Patients". The Journal of Infectious Diseases. 179 Suppl 1 (179): S18 – S23. doi:10.1086/514298. PMID 9988160.
- ^ Young, Lowell S. (1 April 1984). "Immunoprophylaxis and serotherapy of bacterial infections". The American Journal of Medicine. 76 (4): 664–671. doi:10.1016/0002-9343(84)90292-4. ISSN 0002-9343. Retrieved 19 January 2025.
- ^ Erichson, Robert B. (December 1961). "SEROTHERAPY IN VIRUS DISEASES". The Lancet. 278 (7217): 1414. doi:10.1016/S0140-6736(61)91238-7. Retrieved 19 January 2025.
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