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Atorvastatin
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| Clinical data | |
|---|---|
| Pronunciation | /əˌtɔːrvəˈstætən/ |
| Trade names | Lipitor, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a600045 |
| License data |
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| Pregnancy category | |
| Routes of administration | By mouth |
| Drug class | Hypolipidemic agent |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 12% |
| Metabolism | Liver (CYP3A4) |
| Elimination half-life | 14 hours |
| Excretion | Bile duct |
| Identifiers | |
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| CAS Number | |
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| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
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| ChEBI | |
| ChEMBL | |
| PDB ligand | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.125.464 |
| Chemical and physical data | |
| Formula | C33H35FN2O5 |
| Molar mass | 558.650 g·mol−1 |
| 3D model (JSmol) | |
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Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels.[6] For the prevention of cardiovascular disease, statins are a first-line treatment.[6] It is taken by mouth.[6]
Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains.[6] Serious side effects may include rhabdomyolysis, liver problems, and diabetes.[6] Use during pregnancy may harm the fetus.[6] Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol.[6]
Atorvastatin was patented in 1986, and approved for medical use in the United States in 1996.[6][7] It is on the World Health Organization's List of Essential Medicines.[8] It is available as a generic medication.[6][9] In 2022, it was the most commonly prescribed medication in the United States, with more than 109 million prescriptions filled for over 27 million people.[10][11] In Australia, it was one of the top ten most prescribed medications between 2017 and 2023.[12]
- ^ a b "Atorvastatin (Lipitor) Use During Pregnancy". Drugs.com. 3 February 2020. Archived from the original on 4 December 2019. Retrieved 26 February 2020.
- ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
- ^ "Lipitor Product information". Health Canada. 10 March 2017. Retrieved 7 February 2025.
- ^ Cite error: The named reference
Lipitor FDA labelwas invoked but never defined (see the help page). - ^ Cite error: The named reference
Lipitor referralwas invoked but never defined (see the help page). - ^ a b c d e f g h i "Atorvastatin Calcium Monograph for Professionals". Drugs.com. AHFS. Archived from the original on 25 October 2010. Retrieved 23 December 2018.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 473. ISBN 9783527607495. Archived from the original on 12 January 2023. Retrieved 10 May 2020.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ Cite error: The named reference
Hit2014was invoked but never defined (see the help page). - ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
- ^ "Atorvastatin Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
- ^ "Medicines in the health system". Australian Institute of Health and Welfare. 2 July 2024. Retrieved 30 September 2024.
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