CYP2E1

CYP2E1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E4E, 3E6I, 3GPH, 3KOH, 3LC4, 3T3Z
Identifiers
Aliases	CYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1
External IDs	OMIM: 124040; MGI: 88607; HomoloGene: 68089; GeneCards: CYP2E1; OMA:CYP2E1 - orthologs
EC number	1.14.13.n7
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 133,520,406 bp[1] End 133,561,220 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F4|7 85.94 cM Start 140,343,652 bp[2] End 140,354,900 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right hemisphere of cerebellum body of pancreas right frontal lobe right uterine tube skin of leg skin of abdomen endothelial cell middle temporal gyrus Brodmann area 9 Top expressed in left lobe of liver tunica adventitia of aorta white adipose tissue right kidney lactiferous gland subcutaneous adipose tissue intercostal muscle human kidney ankle joint tunica media of zone of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding oxygen binding arachidonic acid epoxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen metal ion binding monooxygenase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enzyme binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen steroid hydroxylase activity Hsp70 protein binding Hsp90 protein binding Cellular component organelle membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle membrane intrinsic component of endoplasmic reticulum membrane Golgi membrane endoplasmic reticulum mitochondrion cytoplasm mitochondrial inner membrane Biological process steroid metabolic process epoxygenase P450 pathway response to ozone heterocycle metabolic process response to organonitrogen compound monoterpenoid metabolic process xenobiotic metabolic process response to ethanol triglyceride metabolic process carbon tetrachloride metabolic process halogenated hydrocarbon metabolic process benzene metabolic process long-chain fatty acid biosynthetic process response to bacterium organic acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1571 13106 Ensembl ENSG00000130649 ENSMUSG00000025479 UniProt P05181 Q05421 RefSeq (mRNA) NM_000773 NM_021282 RefSeq (protein) NP_000764 NP_067257 Location (UCSC) Chr 10: 133.52 – 133.56 Mb Chr 7: 140.34 – 140.35 Mb PubMed search [3] [4]
Wikidata
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Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown of foreign compounds in mammals.^[5]

While CYP2E1 itself carries out a relatively low number of these reactions (~4% of known P450-mediated drug oxidations), it and related enzymes CYP1A2 and CYP3A4 are responsible for the breakdown of many toxic environmental chemicals and carcinogens that enter the body, in addition to basic metabolic reactions such as fatty acid oxidations.^[6]

CYP2E1 protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.^[7]