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Carisoprodol

Carisoprodol
Clinical data
Pronunciation/kərˌaɪsʌˈproʊdɒl/
kahr-EYE-suh-PROH-dol
Trade namesSoma, others[1]
AHFS/Drugs.comMonograph
MedlinePlusa682578
License data
Addiction
liability		Low[2][failed verification]
Routes of
administration		By mouth[3]
Drug classMuscle relaxant[3]
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding60%
MetabolismLiver (CYP2C19-mediated)
MetabolitesMeprobamate
Onset of actionRapid (30 minutes[5][failed verification])
Elimination half-life2.5 hours [12 hours[nb 1]]
ExcretionKidney
Identifiers
  • (RS)-2-{[(aminocarbonyl)oxy]methyl}-2-methylpentyl isopropylcarbamate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.001.017 Edit this at Wikidata
Chemical and physical data
FormulaC12H24N2O4
Molar mass260.334 g·mol−1
3D model (JSmol)
  • O=C(N)OCC(C)(CCC)COC(=O)NC(C)C
  • InChI=1S/C12H24N2O4/c1-5-6-12(4,7-17-10(13)15)8-18-11(16)14-9(2)3/h9H,5-8H2,1-4H3,(H2,13,15)(H,14,16) checkY
  • Key:OFZCIYFFPZCNJE-UHFFFAOYSA-N checkY
  (verify)


Carisoprodol, sold under the brand name Soma among others, is a medication used for musculoskeletal pain.[6] Effects generally begin within half an hour and last for up to six hours.[6] It is taken orally (by mouth).[6]

Common side effects include headache, dizziness, and sleepiness.[6] Serious side effect may include addiction, allergic reactions, and seizures.[6] In people with a sulfa allergy certain formulations may result in problems.[6] Safety during pregnancy and breastfeeding is not clear.[6][7] How it works is not clear.[6] Some of its effects are believed to occur following metabolic conversion into meprobamate, carisoprodol's main active metabolite.[6]

Carisoprodol was approved for medical use in the United States in 1959.[6] Its approval in the European Union was withdrawn in 2008.[8] It is available as a generic medication.[6] In 2019, it was the 343rd most commonly prescribed medication in the United States, with more than 800 thousand prescriptions.[9] In the United States, it is a Schedule IV controlled substance.[6]

  1. ^ "Carisoprodol". drugs.com. Retrieved 16 April 2017.
  2. ^ "Drug Scheduling". U.S. Drug Enforcement Administration (DEA). Retrieved 24 March 2024.
  3. ^ a b c "Soma- carisoprodol tablet". DailyMed. 15 May 2023. Retrieved 20 May 2024.
  4. ^ "Soma Product information". Health Canada. 14 March 2003. Retrieved 20 May 2024.
  5. ^ a b Carrasco A (13 September 2019). "Letra C (Carisoprodol)". In Carrasco Ruiz MA, Chavez Pulido X, Morales E (eds.). Diccionario de Especialidades Farmaceúticas PLM (in Spanish). Vol. I (65th ed.). Mexico City: PLM Latinoamérica. p. 222. ISBN 978-607-625-072-3. Retrieved 13 June 2021.
  6. ^ a b c d e f g h i j k l "Carisoprodol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 8 April 2019.
  7. ^ "DailyMed - carisoprodol tablet". dailymed.nlm.nih.gov. Retrieved 8 April 2019.
  8. ^ "Carisoprodol". European Medicines Agency. 15 November 2007. Retrieved 8 April 2019.
  9. ^ "Carisoprodol - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.


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كاريسوبرودول Arabic كاريزوبرودول AZB Carisoprodol CY Carisoprodol German Carisoprodol Spanish کاریسوپرودول FA Karisoprodoli Finnish Carisoprodol French Karisoprodol ID Carisoprodol IG

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