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Coverage (genetics)
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In genetics, coverage is one of several measures of the depth or completeness of DNA sequencing, and is more specifically expressed in any of the following terms:
- Sequence coverage (or depth) is the number of unique reads that include a given nucleotide in the reconstructed sequence.[1][2] Deep sequencing refers to the general concept of aiming for high number of unique reads of each region of a sequence.[3]
- Physical coverage, the cumulative length of reads or read pairs expressed as a multiple of genome size.[4]
- Genomic coverage, the percentage of all base pairs or loci of the genome covered by sequencing.
- ^ "Sequencing Coverage". illumina.com. Illumina education. Retrieved 2020-10-08.
- ^ Sims, David; Sudbery, Ian; Ilott, Nicholas E.; Heger, Andreas; Ponting, Chris P. (2014). "Sequencing depth and coverage: key considerations in genomic analyses". Nature Reviews Genetics. 15 (2): 121–132. doi:10.1038/nrg3642. PMID 24434847. S2CID 13325739.
- ^ Mardis, Elaine R. (2008-09-01). "Next-Generation DNA Sequencing Methods". Annual Review of Genomics and Human Genetics. 9 (1): 387–402. doi:10.1146/annurev.genom.9.081307.164359. ISSN 1527-8204. PMID 18576944.
- ^ Cite error: The named reference
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