Fas receptor

FAS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DDF, 3EWT, 3EZQ, 3THM, 3TJE, 2NA7
Identifiers
Aliases	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6, Fas cell surface death receptor
External IDs	OMIM: 134637; MGI: 95484; HomoloGene: 27; GeneCards: FAS; OMA:FAS - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	89,029,605 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	34,327,772 bp
RNA expression pattern
	Top expressed in
	rectum; ; left ovary; ; right ovary; ; gallbladder; ; epithelium of nasopharynx; ; right lung; ; left adrenal gland; ; stromal cell of endometrium; ; right adrenal cortex; ; left adrenal cortex;
	Top expressed in
	granulocyte; ; thymus; ; right lung lobe; ; tunica media of zone of aorta; ; seminal vesicula; ; intercostal muscle; ; duodenum; ; jejunum; ; brown adipose tissue; ; white adipose tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	kinase binding; protein binding; transmembrane signaling receptor activity; signal transducer activity; identical protein binding; tumor necrosis factor-activated receptor activity; tumor necrosis factor binding; calmodulin binding; signaling receptor activity;
Cellular component	CD95 death-inducing signaling complex; membrane; extracellular region; cell surface; extracellular exosome; integral component of membrane; plasma membrane; integral component of plasma membrane; external side of plasma membrane; death-inducing signaling complex; membrane raft; cytosol; nuclear body; mitochondrion;
Biological process	renal system process; activation-induced cell death of T cells; tumor necrosis factor-mediated signaling pathway; T cell homeostasis; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; cellular response to mechanical stimulus; circadian rhythm; apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway; regulation of extrinsic apoptotic signaling pathway via death domain receptors; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; spleen development; negative thymic T cell selection; regulation of lymphocyte differentiation; necroptotic signaling pathway; motor neuron apoptotic process; inflammatory response; regulation of myeloid cell differentiation; protein homooligomerization; response to toxic substance; B cell mediated immunity; neuron apoptotic process; positive regulation of protein homooligomerization; cellular response to lithium ion; positive regulation of lymphocyte apoptotic process; negative regulation of apoptotic process; immune response; gene expression; cellular response to hyperoxia; negative regulation of B cell activation; response to glucocorticoid; extrinsic apoptotic signaling pathway in absence of ligand; inflammatory cell apoptotic process; immunoglobulin production; signal transduction; hepatocyte apoptotic process; response to lipopolysaccharide; extrinsic apoptotic signaling pathway; regulation of apoptotic process; positive regulation of apoptotic process; regulation of cell population proliferation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; multicellular organism development; extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of protein phosphorylation; regulation of stress-activated MAPK cascade; cellular response to amino acid starvation; Fas signaling pathway; positive regulation of apoptotic signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	355
	14102
	ENSG00000026103
	ENSMUSG00000024778
	P25445
	P25446
NM_000043; NM_152871; NM_152872; NM_152873; NM_152874;
	NM_152875; NM_152876; NM_152877; NM_001320619
	NM_001146708; NM_007987
	NP_000034; NP_001307548; NP_690610; NP_690611
	NP_001140180; NP_032013
	Wikidata
View/Edit Human	View/Edit Mouse

The Fas receptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a protein that in humans is encoded by the FAS gene.^[5]^[6] Fas was first identified using a monoclonal antibody generated by immunizing mice with the FS-7 cell line. Thus, the name Fas is derived from FS-7-associated surface antigen.^[7]

The Fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis) if it binds its ligand, Fas ligand (FasL). It is one of two apoptosis pathways, the other being the mitochondrial pathway.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000026103 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024778 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lichter P, Walczak H, Weitz S, Behrmann I, Krammer PH (September 1992). "The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19". Genomics. 14 (1): 179–80. doi:10.1016/S0888-7543(05)80302-7. PMID 1385299.
^ Inazawa J, Itoh N, Abe T, Nagata S (November 1992). "Assignment of the human Fas antigen gene (Fas) to 10q24.1". Genomics. 14 (3): 821–2. doi:10.1016/S0888-7543(05)80200-9. PMID 1385309.
^ Nagata S (July 2004). "Early work on the function of CD95, an interview with Shige Nagata". Cell Death and Differentiation. 11 (Suppl 1): S23-7. doi:10.1038/sj.cdd.4401453. PMID 15143352.
^ Wajant H (May 2002). "The Fas signaling pathway: more than a paradigm". Science. 296 (5573): 1635–6. Bibcode:2002Sci...296.1635W. doi:10.1126/science.1071553. PMID 12040174. S2CID 29449108.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000026103 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024778 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1385299-5] Lichter P, Walczak H, Weitz S, Behrmann I, Krammer PH (September 1992). "The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19". Genomics. 14 (1): 179–80. doi:10.1016/S0888-7543(05)80302-7. PMID 1385299.

[pmid1385309-6] Inazawa J, Itoh N, Abe T, Nagata S (November 1992). "Assignment of the human Fas antigen gene (Fas) to 10q24.1". Genomics. 14 (3): 821–2. doi:10.1016/S0888-7543(05)80200-9. PMID 1385309.

[7] Nagata S (July 2004). "Early work on the function of CD95, an interview with Shige Nagata". Cell Death and Differentiation. 11 (Suppl 1): S23-7. doi:10.1038/sj.cdd.4401453. PMID 15143352.

[8] Wajant H (May 2002). "The Fas signaling pathway: more than a paradigm". Science. 296 (5573): 1635–6. Bibcode:2002Sci...296.1635W. doi:10.1126/science.1071553. PMID 12040174. S2CID 29449108.

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Fas receptor

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