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Hypophysectomy
| Hypophysectomy | |
|---|---|
| ICD-9-CM | 07.6 |
| MeSH | D007016 |
Hypophysectomy is the surgical removal of the hypophysis (pituitary gland). It is most commonly performed to treat tumors, especially craniopharyngioma tumors.[1] Sometimes it is used to treat Cushing's syndrome due to pituitary adenoma[2] or Simmond's disease[3] It is also applied in neurosciences (in experiments with lab animals) to understand the functioning of hypophysis. There are various ways a hypophysectomy can be carried out. These methods include transsphenoidal hypophysectomy, open craniotomy, and stereotactic radiosurgery.
Medications that are given as hormone replacement therapy following a complete hypophysectomy (removal of the pituitary gland) are often glucocorticoids.[4] Secondary Addison's and hyperlipidemia can occur. Thyroid hormone is useful in controlling cholesterol metabolism that has been affected by pituitary deletion.[5]
- ^ Jaffe, CA (2006). "Clinically non-functioning pituitary adenoma". Pituitary. 9 (4): 317–21. doi:10.1007/s11102-006-0412-9. PMID 17082898. S2CID 2169345.
- ^ Buchfelder, M; Schlaffer, S (2010). "Pituitary surgery for Cushing's disease" (PDF). Neuroendocrinology. 92 (Suppl 1): 102–6. doi:10.1159/000314223. PMID 20829628.
- ^ "Discussion on Simmonds's Disease. [ Summary ]". Proceedings of the Royal Society of Medicine. 41 (4): 187–195. April 1948. doi:10.1177/003591574804100401. ISSN 0035-9157.
- ^ "Pituitary service: Transsphenoidal hypophysectomy" (PDF). uclh.nhs.uk. June 2014. Retrieved 22 February 2020.
- ^ "Dramatically Increased Intestinal Absorption of Cholesterol Following Hypophysectomy Is Normalized by Thyroid Hormone". Archived from the original (PDF) on 2013-10-15. Retrieved 2013-10-15.
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