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Hypromellose

"HPMC" redirects here. For other uses, see HPMC (disambiguation).
Hypromellose
Names
Other names
Hydroxypropyl methylcellulose; hydroxypropyl methyl cellulose; HPMC; E464
Identifiers
ChemSpider
ECHA InfoCard 100.115.379 Edit this at Wikidata
EC Number
  • 618-389-6
E number E464 (thickeners, ...)
UNII
  • InChI=1S/C36H70O19.C20H38O11/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41;1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-8)17(26-6)16(14)25-5/h19-44H,9-18H2,1-8H3;11-20H,9-10H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27-,28-,29-,30-,31+,32+,33-,34-,35-,36+;11-,12-,13-,14-,15+,16+,17-,18-,19-,20+/m11/s1 checkY
    Key: PUSNGFYSTWMJSK-GSZQVNRLSA-N checkY
  • InChI=1/C36H70O19.C20H38O11/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41;1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-8)17(26-6)16(14)25-5/h19-44H,9-18H2,1-8H3;11-20H,9-10H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27-,28-,29-,30-,31+,32+,33-,34-,35-,36+;11-,12-,13-,14-,15+,16+,17-,18-,19-,20+/m11/s1
    Key: PUSNGFYSTWMJSK-GSZQVNRLBE
Properties
variable
Molar mass variable
Pharmacology
S01KA02 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.[1][2]

HPMC has a cellulose backbone with substituents that enhance its water solubility and stability, making it suitable for various applications. [3]

As a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin.[4] Its Codex Alimentarius code (E number) is E464.

  1. ^ de Silva DJ, Olver JM (July 2005). "Hydroxypropyl methylcellulose (HPMC) lubricant facilitates insertion of porous spherical orbital implants". Ophthal Plast Reconstr Surg. 21 (4): 301–2. doi:10.1097/01.iop.0000170417.19223.6c. PMID 16052145.
  2. ^ Williams RO, Sykora MA, Mahaguna V (2001). "Method to recover a lipophilic drug from hydroxypropyl methylcellulose matrix tablets". AAPS PharmSciTech. 2 (2): 29–37. doi:10.1208/pt020208. PMC 2750474. PMID 14727883.
  3. ^ "HPMC Factory | Premium Hydroxypropyl Methyl Cellulose". SHANDONG LANDU NEW MATERIAL CO.,LTD. Retrieved 2024-12-28.
  4. ^ NOSB TAP Review Compiled by OMRI: Hydroxypropyl Methylcellulose

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هيدروكسي بروبيل ميثيل سيللوز Arabic Hydroxypropylmethylcellulose Danish Hydroxypropylmethylcellulose German Hipromelosa Spanish اشک مصنوعی FA Hydroksipropyylimetyyliselluloosa Finnish Hypromellose French Hidroxipropil-metilcellulóz Hungarian Hidroksipropil metilselulosa ID 하이프로멜로스 Korean

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