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Interleukin 12
| Human Interleukin 12 | |
|---|---|
 Crystal structure of human IL-12 (red helices) | |
| Identifiers | |
| Symbol | IL12, p70 |
| PDB | 1F45 |
| IL12A | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL12A | ||||||
| Alt. symbols | CLMF1, NKSF1, p35 | ||||||
| NCBI gene | 3592 | ||||||
| HGNC | 5969 | ||||||
| OMIM | 161560 | ||||||
| RefSeq | NM_000882 | ||||||
| UniProt | P29459 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p12-q13.2 | ||||||
| |||||||
| interleukin 12B | |||||||
|---|---|---|---|---|---|---|---|
 Crystal structure of IL-12B | |||||||
| Identifiers | |||||||
| Symbol | IL12B | ||||||
| Alt. symbols | CLMF2, NKSF2, p40 | ||||||
| NCBI gene | 3593 | ||||||
| HGNC | 5970 | ||||||
| OMIM | 161561 | ||||||
| PDB | 1F42 | ||||||
| RefSeq | NM_002187 | ||||||
| UniProt | P29460 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q31.1-33.1 | ||||||
| |||||||
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells,[1] macrophages, neutrophils, helper T cells and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35.[2] Despite sharing many structural features and molecular partners, they mediate surprisingly diverse functional effects.
- ^ Kaliński P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML (July 1997). "IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells". Journal of Immunology. 159 (1): 28–35. doi:10.4049/jimmunol.159.1.28. PMID 9200435. S2CID 10617490.
- ^ Vignali DA, Kuchroo VK (July 2012). "IL-12 family cytokines: immunological playmakers". Nature Immunology. 13 (8): 722–8. doi:10.1038/ni.2366. PMC 4158817. PMID 22814351.
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