Keen-Minshull is the founder of the group Standing for Women[8][9] and the former special advisor to the Women's Liberation Front (WoLF). She has been described as a key figure opposing the United Kingdom's Gender Recognition Act 2004. She has been credited for popularising the use of the term "adult human female" to define a woman; the term later became associated with gender-critical feminism. She launched a failed bid to become the MP for the constituency of Bristol Central in the 2024 United Kingdom general election, coming in last place with only 0.5% of the vote.[10]
She has used billboards, posters, stickers and social media to promote anti-transgender rights messages, and has held events in the United Kingdom, the United States, Australia, and New Zealand that have been protested against by supporters of transgender rights.