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Liothyronine

This article is about liothyronine as a medication. For the hormone, see Triiodothyronine.

Liothyronine
Clinical data
Trade namesCytomel, Tertroxin, others
AHFS/Drugs.comMonograph
MedlinePlusa682462
License data
Routes of
administration		By mouth, intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding99.7%
Elimination half-life2.5 days
Identifiers
  • (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.000.203 Edit this at Wikidata
Chemical and physical data
FormulaC15H12I3NO4
Molar mass650.977 g·mol−1
3D model (JSmol)
  • C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)O)N)I)I)O
  • InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 checkY
  • Key:AUYYCJSJGJYCDS-LBPRGKRZSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Liothyronine is a manufactured form of the thyroid hormone triiodothyronine (T3).[2] It is most commonly used to treat hypothyroidism and myxedema coma.[2] It can be taken by mouth or by injection into a vein.[2]

Side effects may occur from excessive doses.[2] This may include weight loss, fever, headache, anxiety, trouble sleeping, arrhythmias, and heart failure.[2] Use in pregnancy and breastfeeding is generally safe.[3][2]

Liothyronine was approved for medical use in 1956.[2] It is available as a generic medication.[3] In 2022, it was the 204th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[4][5]

  1. ^ "Cytomel Product information". Health Canada. 20 March 2013. Retrieved 9 January 2025.
  2. ^ a b c d e f g "Liothyronine Sodium Monograph for Professionals". Drugs.com. Retrieved 27 February 2019.
  3. ^ a b British National Formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 757. ISBN 9780857113382.
  4. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  5. ^ "Liothyronine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.

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ليوثيرونين Arabic Liotironina sódica Spanish لیوتیرونین FA Liotyroniini Finnish Liothyronine sodique French Liotironin ID Liotironina Italian リオチロニン Japanese Liotironina Malay ଲିଓଥାଇରୋନିନ OR

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