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Malonic ester synthesis
| Malonic ester synthesis | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reaction type | Coupling reaction | ||||||||||||||
| Reaction | |||||||||||||||
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| Conditions | |||||||||||||||
| Temperature | +Δ[1]
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| Identifiers | |||||||||||||||
| Organic Chemistry Portal | malonic-ester-synthesis | ||||||||||||||
| RSC ontology ID | RXNO:0000107 | ||||||||||||||
The malonic ester synthesis is a chemical reaction where diethyl malonate or another ester of malonic acid is alkylated at the carbon alpha (directly adjacent) to both carbonyl groups, and then converted to a substituted acetic acid.[2]
A major drawback of malonic ester synthesis is that the alkylation stage can also produce dialkylated structures. This makes separation of products difficult and yields lower.[3]
- ^ Cite error: The named reference
heat conditionwas invoked but never defined (see the help page). - ^ House, Herbert O. (1972). Modern Synthetic Reactions. Menlo Park, CA.: W. A. Benjamin. ISBN 0-8053-4501-9.
- ^ Malonic Ester Synthesis – Alkylation of Enolates
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