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Mebendazole
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| Clinical data | |
|---|---|
| Trade names | Vermox,[1] Ovex, others |
| Other names | MBZ |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682315 |
| License data |
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| Pregnancy category |
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| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 2–10% |
| Protein binding | 95% |
| Metabolism | Extensive liver |
| Elimination half-life | 3–6 hours |
| Excretion | Feces, urine (5–10%) |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.046.017 |
| Chemical and physical data | |
| Formula | C16H13N3O3 |
| Molar mass | 295.298 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 288.5 °C (551.3 °F) |
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Mebendazole (MBZ), sold under the brand name Vermox among others, is a medication used to treat a number of parasitic worm infestations.[5] This includes ascariasis, pinworm infection, hookworm infections, guinea worm infections and hydatid disease, among others.[5] It has been used for treatment of giardiasis but is not a preferred agent.[6][7] It is taken by mouth.[5]
Mebendazole is usually well tolerated.[5] Common side effects include headache, vomiting, and ringing in the ears.[5] If used at large doses it may cause bone marrow suppression.[5] It is unclear if it is safe in pregnancy.[5][2] Mebendazole is a broad-spectrum antihelminthic agent of the benzimidazole type.[5]
Mebendazole came into use in 1971, after it was developed by Janssen Pharmaceutica in Belgium.[8] It is on the World Health Organization's List of Essential Medicines.[9] Mebendazole is available as a generic medication.[10]
- ^ Ebadi M (2008). Desk reference of clinical pharmacology (2nd ed.). Boca Raton: CRC Press. p. 403. ISBN 9781420047448. Archived from the original on 8 September 2017.
- ^ a b "Mebendazole Use During Pregnancy". Drugs.com. 29 July 2020. Archived from the original on 28 October 2020. Retrieved 30 September 2020.
- ^ "Vermox Product information". Health Canada. 25 April 2012. Archived from the original on 13 May 2021. Retrieved 12 June 2022.
- ^ "Mebendazole". Archived from the original on 23 October 2016. Retrieved 29 April 2016.
- ^ a b c d e f g h ASHP (3 June 2024). "Mebendazole". The American Society of Health-System Pharmacists. Archived from the original on 7 September 2015. Retrieved 12 December 2024.
- ^ ASHP. "Mebendazole". The American Society of Health-System Pharmacists. Archived from the original on 7 September 2015.
- ^ "Patient Care for Giardia Infection". Giardia. U.S. Centers for Disease Control and Prevention. 20 February 2024. Retrieved 12 December 2024.
- ^ Mehlhorn, Heinz (2001). Encyclopedic reference of parasitology. 107 tables (2 ed.). Berlin [u.a.]: Springer. p. 259. ISBN 9783540668299. Archived from the original on 8 September 2017.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ Hamilton, Richard J. (2012). Tarascon pocket pharmacopoeia (13 ed.). Burlington, Mass.: Jones & Bartlett Learning. p. 33. ISBN 9781449624286. Archived from the original on 8 September 2017.
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