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Medullary thyroid cancer
| Medullary thyroid cancer | |
|---|---|
| Other names | MTC |
 | |
| Micrograph of medullary thyroid carcinoma with amyloid deposition (left of image). Near normal thyroid follicles are also seen (right of image). H&E stain. | |
| Specialty | ENT surgery |
Medullary thyroid cancer is a form of thyroid carcinoma which originates from the parafollicular cells (C cells), which produce the hormone calcitonin.[1] Medullary tumors are the third most common of all thyroid cancers and together make up about 3% of all thyroid cancer cases.[2] MTC was first characterized in 1959.[3]
Approximately 25% of medullary thyroid cancer cases are genetic in nature, caused by a mutation in the RET proto-oncogene. When MTC occurs by itself it is termed sporadic medullary thyroid cancer. Medullary thyroid cancer is seen in people with multiple endocrine neoplasia type 2A and 2B. When medullary thyroid cancer due to a hereditary genetic disorder occurs without other endocrine tumours it is termed familial medullary thyroid cancer.
- ^ Hu MI, Vassilopoulou-Sellin R, Lustig R, Lamont JP. "Thyroid and Parathyroid Cancers" in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer Management: A Multidisciplinary Approach. 11 ed. 2008.
- ^ Stamatakos M, Paraskeva P, Stefanaki C, Katsaronis P, Lazaris A, Safioleas K, Kontzoglou K (January 2011). "Medullary thyroid carcinoma: The third most common thyroid cancer reviewed". Oncol Lett. 2 (1): 49–53. doi:10.3892/ol.2010.223. PMC 3412473. PMID 22870127.
- ^ Dionigi G, Bianchi V, Rovera F, et al. (2007). "Medullary thyroid carcinoma: surgical treatment advances". Expert Rev Anticancer Ther. 7 (6): 877–85. doi:10.1586/14737140.7.6.877. PMID 17555398. S2CID 37519975.
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سرطان الغدة الدرقية النخاعي Arabic Medulyar tiroid xərçəng AZ Cáncer medular tiroideo Spanish Վահանագեղձի մեդուլյար քաղցկեղ HY Carcinoma midollare della tiroide Italian 갑상샘수질암 Korean Rak rdzeniasty tarczycy Polish Carcinoma medular da tiroide Portuguese Медулярний рак щитоподібної залози Ukrainian 甲狀腺髓質癌 Chinese
