Our website is made possible by displaying online advertisements to our visitors.
Please consider supporting us by disabling your ad blocker.

Responsive image


Opioid receptor

An animated view of the human κ-opioid receptor in complex with the antagonist JDTic.

Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands.[1][2][3] The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are ~40% identical to somatostatin receptors (SSTRs). Opioid receptors are distributed widely in the brain, in the spinal cord, on peripheral neurons, and digestive tract.

  1. ^ Dhawan BN, Cesselin F, Raghubir R, Reisine T, Bradley PB, Portoghese PS, Hamon M (December 1996). "International Union of Pharmacology. XII. Classification of opioid receptors". Pharmacological Reviews. 48 (4): 567–92. PMID 8981566.Open access icon
  2. ^ Janecka A, Fichna J, Janecki T (2004). "Opioid receptors and their ligands". Current Topics in Medicinal Chemistry. 4 (1): 1–17. doi:10.2174/1568026043451618. PMID 14754373.Open access icon
  3. ^ Waldhoer M, Bartlett SE, Whistler JL (2004). "Opioid receptors". Annual Review of Biochemistry. 73: 953–90. doi:10.1146/annurev.biochem.73.011303.073940. PMID 15189164.Closed access icon

Previous Page Next Page