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Phenomics
 | This article may require cleanup to meet Wikipedia's quality standards. The specific problem is: References need to be checked whether they actually support the statements made. I checked a few and neither even mentioned "phenome" or "phenomics". (August 2023) |
Phenomics is the systematic study of traits that make up an organisms phenotype, [1] [2] which changes over time, due to development and aging or through metamorphosis such as when a caterpillar changes into a butterfly. The term phenomics was coined by UC Berkeley and LBNL scientist Steven A. Garan.[3][4] As such, it is a transdisciplinary area of research that involves biology, data sciences, engineering and other fields. Phenomics is concerned with the measurement of the phenotype where a phenome is a set of traits (physical and biochemical traits) that can be produced by a given organism over the course of development and in response to genetic mutation and environmental influences.
An organism's phenotype changes with time. The relationship between phenotype and genotype enables researchers to understand and study pleiotropy.[5] Phenomics concepts are used in functional genomics, pharmaceutical research, metabolic engineering, agricultural research, and increasingly in phylogenetics.[6]
Technical challenges involve improving, both qualitatively and quantitatively, the capacity to measure phenomes.[5]
- ^ Bilder, R.M.; Sabb, F.W.; Cannon, TD; London, ED; Jentsch, JD; Parker, DS; Poldrack, RA; Evans, C; Freimer, NB (2009). "Phenomics: The systematic study of phenotypes on a genome-wide scale". Neuroscience. 164 (1): 30–42. doi:10.1016/j.neuroscience.2009.01.027. PMC 2760679. PMID 19344640.
- ^ Houle, David; Govindaraju, Diddahally R.; Omholt, Stig (2010). "Phenomics: the next challenge". Nature Reviews Genetics. 11 (12): 855–866. doi:10.1038/nrg2897. PMID 21085204.
- ^ Jin, Li (2021-02-01). "Welcome to the Phenomics Journal". Phenomics. 1 (1): 1–2. doi:10.1007/s43657-020-00009-4. ISSN 2730-5848. PMC 9584128. PMID 36939790.
- ^ Guanghui, Yu; Xuanjun, Fang (2009). "Concept of phenomics and its development in plant science". Molecular Plant Breeding. ISSN 1672-416X – via The Food and Agriculture Organization (FAO) is a specialized agency of the United Nations.
- ^ a b Houle, David; Govindaraju, Diddahally R.; Omholt, Stig (2010). "Phenomics: the next challenge". Nature Reviews Genetics. 11 (12): 855–866. doi:10.1038/nrg2897. PMID 21085204. S2CID 14752610.
- ^ O'Leary, M. A.; Bloch, J. I.; Flynn, J. J.; Gaudin, T. J.; Giallombardo, A.; Giannini, N. P.; Goldberg, S. L.; Kraatz, B. P.; Luo, Z.-X.; Meng, J.; Ni, X.; Novacek, M. J.; Perini, F. A.; Randall, Z.; Rougier, G. W.; Sargis, E. J.; Silcox, M. T.; Simmons, N. B.; Spaulding, M.; Velazco, P. M.; Weksler, M.; Wible, J. R.; Cirranello, A. L. (2013). "The placental mammal ancestor and the post-K-Pg radiation of placentals". Science. 332 (6120): 662–667. Bibcode:2013Sci...339..662O. doi:10.1126/science.1229237. hdl:11336/7302. PMID 23393258. S2CID 206544776.
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