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Piwi
| Piwi domain | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Structure of the Pyrococcus furiosus Argonaute protein.[1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | Piwi | ||||||||||
| Pfam | PF02171 | ||||||||||
| InterPro | IPR003165 | ||||||||||
| PROSITE | PS50822 | ||||||||||
| CDD | cd02826 | ||||||||||
| |||||||||||
Piwi (or PIWI) genes were identified as regulatory proteins responsible for stem cell and germ cell differentiation.[4] Piwi is an abbreviation of P-element Induced WImpy testis[a] in Drosophila.[6] Piwi proteins are highly conserved RNA-binding proteins and are present in both plants and animals.[7] Piwi proteins belong to the Argonaute/Piwi family and have been classified as nuclear proteins. Studies on Drosophila have also indicated that Piwi proteins have no slicer activity conferred by the presence of the Piwi domain.[8] In addition, Piwi associates with heterochromatin protein 1, an epigenetic modifier, and piRNA-complementary sequences. These are indications of the role Piwi plays in epigenetic regulation. Piwi proteins are also thought to control the biogenesis of piRNA as many Piwi-like proteins contain slicer activity which would allow Piwi proteins to process precursor piRNA into mature piRNA.
- ^ Rivas FV, Tolia NH, Song JJ, et al. (April 2005). "Purified Argonaute2 and an siRNA form recombinant human RISC". Nat. Struct. Mol. Biol. 12 (4): 340–9. doi:10.1038/nsmb918. PMID 15800637. S2CID 2021813.
- ^ "Uniprot: The Universal knowledge database". Nucleic Acids Research. 45 (D1): D158 – D169. 2017. doi:10.1093/nar/gkw1099. PMC 5210571. PMID 27899622.
- ^ Lindse K (2013). "Piwi-RNAs, the Defenders of the Genome".
{{cite journal}}: Cite journal requires|journal=(help) - ^ Cox DN, Chao A, Lin H (2000). "piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells". Development. 127 (3): 503–14. doi:10.1242/dev.127.3.503. PMID 10631171.
- ^ Ross RJ, Weiner MM, Lin H (2014). "PIWI proteins and PIWI-interacting RNAs in the soma". Nature. 505 (7483): 353–359. Bibcode:2014Natur.505..353R. doi:10.1038/nature12987. PMC 4265809. PMID 24429634.
- ^ Lin H, Spradling AC (1997). "A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary". Development. 124 (12): 2463–2476. doi:10.1242/dev.124.12.2463. PMID 9199372.
- ^ Cox DN, Chao A, Baker J, Chang L, Qiao D, Lin H (1998). "A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal". Genes Dev. 12 (23): 3715–27. doi:10.1101/gad.12.23.3715. PMC 317255. PMID 9851978.
- ^ Darricarrere N, Liu N, Watanabe T, Lin H (2013). "Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity". Proc Natl Acad Sci USA. 110 (6): 1297–1302. Bibcode:2013PNAS..110.1297D. doi:10.1073/pnas.1213283110. PMC 3557079. PMID 23297219.
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