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Protein targeting
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the cell.[1][2][note 1] Proteins can be targeted to the inner space of an organelle, different intracellular membranes, the plasma membrane, or to the exterior of the cell via secretion.[1][2] Information contained in the protein itself directs this delivery process.[2][3] Correct sorting is crucial for the cell; errors or dysfunction in sorting have been linked to multiple diseases.[2][4][5]
- ^ a b Nelson DL (January 2017). Lehninger principles of biochemistry. Cox, Michael M.,, Lehninger, Albert L. (Seventh ed.). New York, NY. ISBN 978-1-4641-2611-6. OCLC 986827885.
{{cite book}}: CS1 maint: location missing publisher (link) - ^ a b c d Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Martin, Yaffe, Amon (2021). Molecular Cell Biology (9th ed.). New York, NY: W.H. Freeman and Company. ISBN 978-1-319-20852-3.
{{cite book}}: CS1 maint: multiple names: authors list (link) - ^ Blobel G, Dobberstein B (December 1975). "Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma". The Journal of Cell Biology. 67 (3): 835–51. doi:10.1083/jcb.67.3.835. PMC 2111658. PMID 811671.
- ^ Schmidt V, Willnow TE (February 2016). "Protein sorting gone wrong--VPS10P domain receptors in cardiovascular and metabolic diseases". Atherosclerosis. 245: 194–9. doi:10.1016/j.atherosclerosis.2015.11.027. PMID 26724530.
- ^ Guo Y, Sirkis DW, Schekman R (2014-10-11). "Protein sorting at the trans-Golgi network". Annual Review of Cell and Developmental Biology. 30 (1): 169–206. doi:10.1146/annurev-cellbio-100913-013012. PMID 25150009.
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