Systemic inflammation

Chronic systemic inflammation (SI) is the result of release of pro-inflammatory cytokines from immune-related cells and the chronic activation of the innate immune system. It can contribute to the development or progression of certain conditions such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, autoimmune and neurodegenerative disorders,^[1] and coronary heart disease.^[2]

^ Furman, David; Campisi, Judith; Verdin, Eric; Carrera-Bastos, Pedro; Targ, Sasha; Franceschi, Claudio; Ferrucci, Luigi; Gilroy, Derek W.; Fasano, Alessio; Miller, Gary W.; Miller, Andrew H. (December 2019). "Chronic inflammation in the etiology of disease across the life span". Nature Medicine. 25 (12): 1822–1832. doi:10.1038/s41591-019-0675-0. ISSN 1546-170X. PMC 7147972. PMID 31806905.
^ Sattar N, McCarey DW, Capell H, McInnes IB (December 2003). "Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis". Circulation. 108 (24): 2957–63. doi:10.1161/01.CIR.0000099844.31524.05. PMID 14676136.