Talk:Amphetamine

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Frequently asked questions

Q1: Lisdexamfetamine is mentioned in the article along with levoamphetamine and dextroamphetamine. Is lisdexamfetamine (brand name: Vyvanse) a form of amphetamine?

A1: No. At the molecular level, lisdexamfetamine has the molecular structure of amphetamine coupled with the amino acid lysine, making it chemically distinct from the amphetamine enantiomers (i.e., levoamphetamine and dextroamphetamine).^[1]

Lisdexamfetamine has the chemical formula C₁₅H₂₅N₃O;^[1] however, amphetamine, dextroamphetamine, and levoamphetamine have the formula C₉H₁₃N.^[2] Consequently, lisdexamfetamine is not an optical isomer of amphetamine like dextroamphetamine and levoamphetamine. As an inactive prodrug, it simply has no effect on the human body until enzymes metabolize it into dextroamphetamine.^[1] This is why it is covered in the article along with the enantiomers.

References

^ ^a ^b ^c "Identification". Lisdexamfetamine. University of Alberta. 16 September 2013. Retrieved 28 September 2014. {{cite encyclopedia}}: |work= ignored (help)
^ "Identification". Amphetamine. University of Alberta. 8 February 2013. Retrieved 28 September 2014. {{cite encyclopedia}}: |work= ignored (help)

This article is written in American English, which has its own spelling conventions (color, defense, traveled) and some terms that are used in it may be different or absent from other varieties of English. According to the relevant style guide, this should not be changed without broad consensus.

Amphetamine is a featured article; it (or a previous version of it) has been identified as one of the best articles produced by the Wikipedia community. Even so, if you can update or improve it, please do so.

This article appeared on Wikipedia's Main Page as Today's featured article on April 3, 2015.

Article milestones
Date	Process	Result
October 19, 2013	Peer review	Reviewed
November 30, 2013	Good article nominee	Listed
January 22, 2014	Featured article candidate	Not promoted
April 21, 2014	Featured article candidate	Not promoted
August 1, 2014	Featured article candidate	Not promoted
October 8, 2014	Featured article candidate	Not promoted
January 14, 2015	Featured article candidate	Promoted
Current status: Featured article

Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Amphetamine.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Section sizes

Section size for Amphetamine (44 sections)
Section name	Byte count	Section total
(Top)	20,107	20,107
Uses	10	77,346
Medical	629	50,467
ADHD	19,441	19,441
Binge eating disorder	16,689	16,689
Narcolepsy	13,708	13,708
Enhancing performance	29	18,590
Cognitive performance	9,628	9,628
Physical performance	8,933	8,933
Recreational	8,279	8,279
Contraindications	4,747	4,747
Adverse effects	708	53,679
Physical	7,943	7,943
Psychological	5,237	5,237
Reinforcement disorders	31	39,791
Addiction	5,631	5,631
Biomolecular mechanisms	15,530	30,647
Pharmacological treatments	7,542	7,542
Behavioral treatments	7,575	7,575
Dependence and withdrawal	3,482	3,482
Overdose	5,375	11,376
Toxicity	4,838	4,838
Psychosis	1,163	1,163
Drug interactions	9,952	9,952
Pharmacology	18	59,617
Pharmacodynamics	18,435	35,272
Dopamine	6,279	6,279
Norepinephrine	806	806
Serotonin	1,213	1,213
Other neurotransmitters, peptides, hormones, and enzymes	8,539	8,539
Pharmacokinetics	12,392	12,392
Pharmacomicrobiomics	7,460	7,460
Related endogenous compounds	4,475	4,475
Chemistry	4,872	25,264
Substituted derivatives	2,641	2,641
Synthesis	9,875	9,875
Detection in body fluids	7,876	7,876
History, society, and culture	7,427	22,276
Legal status	6,269	6,269
Pharmaceutical products	8,580	8,580
Notes	98	98
Reference notes	49	49
References	28	28
External links	1,751	1,751
Total	286,290	286,290

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[Vyvanse-1] "Identification". Lisdexamfetamine. University of Alberta. 16 September 2013. Retrieved 28 September 2014. {{cite encyclopedia}}: |work= ignored (help)

[DrugBank1-2] "Identification". Amphetamine. University of Alberta. 8 February 2013. Retrieved 28 September 2014. {{cite encyclopedia}}: |work= ignored (help)

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Talk:Amphetamine

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