VKORC1

VKORC1
Identifiers
Aliases	VKORC1, EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR, vitamin K epoxide reductase complex subunit 1
External IDs	OMIM: 608547; MGI: 106442; HomoloGene: 11416; GeneCards: VKORC1; OMA:VKORC1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 31,090,842 bp[1] End 31,095,980 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 69.81 cM Start 127,492,235 bp[2] End 127,494,789 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right lobe of liver thoracic aorta ascending aorta Descending thoracic aorta right coronary artery body of pancreas left coronary artery right ovary Pituitary Gland Top expressed in primary oocyte secondary oocyte zygote islet of Langerhans yolk sac urinary bladder liver right kidney proximal tubule white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity vitamin-K-epoxide reductase (warfarin-sensitive) activity quinone binding vitamin-K-epoxide reductase (warfarin-insensitive) activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum intracellular membrane-bounded organelle Biological process peptidyl-glutamic acid carboxylation blood coagulation bone development vitamin K metabolic process response to organonitrogen compound response to organic cyclic compound regulation of blood coagulation response to antibiotic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79001 27973 Ensembl ENSG00000167397 ENSMUSG00000096145 UniProt Q9BQB6 Q9CRC0 RefSeq (mRNA) NM_001311311 NM_024006 NM_206824 NM_178600 RefSeq (protein) NP_001298240 NP_076869 NP_996560 NP_848715 Location (UCSC) Chr 16: 31.09 – 31.1 Mb Chr 7: 127.49 – 127.49 Mb PubMed search [3] [4]
Wikidata
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The human gene VKORC1 encodes for the enzyme, Vitamin K epOxide Reductase Complex (VKORC) subunit 1.^[5] This enzymatic protein complex is responsible for reducing vitamin K 2,3-epoxide to its active form, which is important for effective clotting (coagulation). In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors.