Valsartan

Valsartan
Clinical data
Trade names	Diovan, others
AHFS/Drugs.com	Monograph
MedlinePlus	a697015
License data	US DailyMed: Valsartan;
Pregnancy; category	AU: D; ;
Routes of; administration	By mouth
Drug class	Angiotensin II receptor antagonist
ATC code	C09CA03 (WHO) C09DX05 (WHO), C09DA03 (WHO), C09DX02 (WHO), C09DX01 (WHO), C09DB08 (WHO), C09DB01 (WHO), C09DX04 (WHO), C10BX10 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Bioavailability	25%
Protein binding	95%
Elimination half-life	6 hours
Excretion	Kidney 30%, bile duct 70%
Identifiers
	IUPAC name (S)-3-methyl-2-(N-{[2'-(2H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl]methyl}pentanamido)butanoic acid;
CAS Number	137862-53-4 ;
PubChem CID	60846;
IUPHAR/BPS	3937; tritiated: 593;
DrugBank	DB00177 ;
ChemSpider	54833 ;
UNII	80M03YXJ7I;
KEGG	D00400 ;
ChEBI	CHEBI:9927 ;
ChEMBL	ChEMBL1069 ;
CompTox Dashboard (EPA)	DTXSID6023735 ;
ECHA InfoCard	100.113.097
Chemical and physical data
Formula	C24H29N5O3
Molar mass	435.528 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(C(=O)O)C(C)C;
	InChI InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1 ; Key:ACWBQPMHZXGDFX-QFIPXVFZSA-N ;
	(verify)

Valsartan, sold under the brand name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.^[8] It belongs to a class of medications referred to as angiotensin II receptor blockers (ARBs). It is a reasonable initial treatment for high blood pressure.^[8] It is taken by mouth.^[8]

Common side effects include feeling tired, dizziness, high blood potassium, diarrhea, and joint pain.^[8] Other serious side effects may include kidney problems, low blood pressure, and angioedema.^[8] Use in pregnancy may harm the baby and use when breastfeeding is not recommended.^[9] It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.^[8]

Valsartan was patented in 1990, and came into medical use in 1996.^[10] It is available as a generic medication.^[11] In 2022, it was the 117th most commonly prescribed medication in the United States, with more than 5 million prescriptions.^[12]^[13]

^ "Valsartan Use During Pregnancy". Drugs.com. 28 March 2019. Retrieved 12 February 2020.
^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^ "Diovan valsartan 40mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.
^ "Diovan valsartan 80mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.
^ "Diovan valsartan 160mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.
^ "Valsartan 160 mg capsules - Summary of Product Characteristics (SmPC)". (emc). 19 February 2019. Archived from the original on 13 February 2020. Retrieved 12 February 2020.
^ Cite error: The named reference Diovan FDA label was invoked but never defined (see the help page).
^ ^a ^b ^c ^d ^e ^f "Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
^ "Valsartan Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
^ Fischer J, Ganellin CR, eds. (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 470. ISBN 9783527607495.
^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 179. ISBN 9780857113382.
^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
^ "Valsartan Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.

[Drugs.com_pregnancy-1] "Valsartan Use During Pregnancy". Drugs.com. 28 March 2019. Retrieved 12 February 2020.

[FDA-AllBoxedWarnings-2] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.

[3] "Diovan valsartan 40mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.

[4] "Diovan valsartan 80mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.

[5] "Diovan valsartan 160mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.

[6] "Valsartan 160 mg capsules - Summary of Product Characteristics (SmPC)". (emc). 19 February 2019. Archived from the original on 13 February 2020. Retrieved 12 February 2020.

[Diovan_FDA_label-7] Cite error: The named reference Diovan FDA label was invoked but never defined (see the help page).

[AHFS2019-8] ^ ^a ^b ^c ^d ^e ^f "Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[Preg2019-9] "Valsartan Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.

[Fis2006-10] Fischer J, Ganellin CR, eds. (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 470. ISBN 9783527607495.

[BNF76-11] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 179. ISBN 9780857113382.

[12] "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.

[13] "Valsartan Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.

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Valsartan

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